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Literature DB >> 31386861

The Hippo Signaling Pathway in Development and Disease.

Abstract

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: NF2; TAZ; TEAD; YAP; actomyosin; adherens junction; cancer; cell polarity; cytoskeleton; growth control; hippo signaling; mechanotransduction; merlin; neurofibromatosis; oncogene; regeneration; scalloped; spectrin; tissue homeostasis; tumor suppressor; yorkie

Mesh：

Substances：

Year: 2019 PMID： 31386861 PMCID： PMC6748048 DOI： 10.1016/j.devcel.2019.06.003

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

259 in total

Review 1. Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling.

Authors: Scott Barolo; James W Posakony
Journal: Genes Dev Date: 2002-05-15 Impact factor: 11.361

2. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.

Authors: A Vassilev; K J Kaneko; H Shu; Y Zhao; M L DePamphilis
Journal: Genes Dev Date: 2001-05-15 Impact factor: 11.361

3. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis.

Authors: Jianhang Jia; Wensheng Zhang; Bing Wang; Richard Trinko; Jin Jiang
Journal: Genes Dev Date: 2003-10-15 Impact factor: 11.361

4. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila.

Authors: Madhuri Kango-Singh; Riitta Nolo; Chunyao Tao; Patrik Verstreken; P Robin Hiesinger; Hugo J Bellen; Georg Halder
Journal: Development Date: 2002-12 Impact factor: 6.868

5. Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.

Authors: M Giovannini; E Robanus-Maandag; M van der Valk; M Niwa-Kawakita; V Abramowski; L Goutebroze; J M Woodruff; A Berns; G Thomas
Journal: Genes Dev Date: 2000-07-01 Impact factor: 11.361

6. salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.

Authors: Nicolas Tapon; Kieran F Harvey; Daphne W Bell; Doke C R Wahrer; Taryn A Schiripo; Daniel A Haber; Iswar K Hariharan
Journal: Cell Date: 2002-08-23 Impact factor: 41.582

7. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway.

Authors: Ryan S Udan; Madhuri Kango-Singh; Riitta Nolo; Chunyao Tao; Georg Halder
Journal: Nat Cell Biol Date: 2003-09-21 Impact factor: 28.824

8. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

Authors: Sophie Pantalacci; Nicolas Tapon; Pierre Léopold
Journal: Nat Cell Biol Date: 2003-09-21 Impact factor: 28.824

9. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.

Authors: Kieran F Harvey; Cathie M Pfleger; Iswar K Hariharan
Journal: Cell Date: 2003-08-22 Impact factor: 41.582

10. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.

Authors: Shian Wu; Jianbin Huang; Jixin Dong; Duojia Pan
Journal: Cell Date: 2003-08-22 Impact factor: 41.582

185 in total

1. Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade.

Authors: Zhihong Chen; Cameron J Herting; James L Ross; Ben Gabanic; Montse Puigdelloses Vallcorba; Frank Szulzewsky; Megan L Wojciechowicz; Patrick J Cimino; Ravesanker Ezhilarasan; Erik P Sulman; Mingyao Ying; Avi Ma'ayan; Renee D Read; Dolores Hambardzumyan
Journal: Glia Date: 2020-07-08 Impact factor: 7.452

The Hippo Signaling Pathway in Development and Disease.

Review 1. Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling.

2. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.

3. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis.

4. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila.

5. Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.

6. salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.

7. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway.

8. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

9. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.

10. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.

1. Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade.

Review 2. Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing.

3. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation.

Review 4. Hippo-YAP signaling in digestive system tumors.

Review 5. Regulatory mechanisms governing epidermal stem cell function during development and homeostasis.

6. Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling.

7. LRP6 lets Merlin go in times of nutrient scarcity.

8. One repressor to rule them all: ANCO1 links YAP and AIB1.

9. Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation.

10. Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis.