| Literature DB >> 31386773 |
S Schreiber1,2,3, A Wilisch-Neumann1,2, F Schreiber1,2, A Assmann1,2, V Scheumann1, V Perosa1,2, S Jandke1,2, C Mawrin4, R O Carare5, D J Werring6.
Abstract
Deep perforator arteriopathy (DPA) and cerebral amyloid angiopathy (CAA) are the commonest known cerebral small vessel diseases (CSVD), which cause ischaemic stroke, intracebral haemorrhage (ICH) and vascular cognitive impairment (VCI). While thus far mainly considered as separate entities, we here propose that DPA and CAA share similarities, overlap and interact, so that 'pure' DPA or CAA are extremes along a continuum of age-related small vessel pathologies. We suggest blood-brain barrier (BBB) breakdown, endothelial damage and impaired perivascular β-amyloid (Aβ) drainage are hallmark common mechanisms connecting DPA and CAA. We also suggest a need for new biomarkers (e.g. high-resolution imaging) to deepen understanding of the complex relationships between DPA and CAA.Entities:
Keywords: blood-brain barrier; cerebral amyloid angiopathy; cerebral small vessel diseases; deep perforator arteriopathy; hypertensive arteriopathy; β-amyloid drainage
Mesh：
Substances：
Year: 2019 PMID： 31386773 DOI： 10.1111/nan.12576
Source DB: PubMed Journal: Neuropathol Appl Neurobiol ISSN： 0305-1846 Impact factor: 8.090