Hanneke Zwinkels1, Linda Dirven1, Thomas Vissers1, Esther J J Habets1, Maaike J Vos1, Jaap C Reijneveld1, Martin J van den Bent1, Martin J B Taphoorn1. 1. Medical Center Haaglanden, Department of Neurology, Lijnbaan 32, 2512 VK The Hague, PO BOX 432, 2501 CK, The Hague, The Netherlands (H.Z., E.J.J.H., M.J.V., M.J.B.T.); Medical Center Haaglanden, Landsteiner Institute, Lijnbaan 32, 2512 VK The Hague, PO BOX 432, 2501 CK, The Hague, The Netherlands (T.V.); Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands (L.D., M.J.B.T.); Department of Neurology, VU Medical Center, de Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands (J.C.R.); Amsterdam Medical Center, Department of Neurology, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands (J.C.R.); Department of Neuro-oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands (M.J.v.d.B.).
Abstract
BACKGROUND: Gliomas are rare, with a dismal outcome and an obvious impact on quality of life, because of neurological, physical and cognitive problems, as well as personality and behavioral changes. These latter changes may affect the lives of both patients and their relatives in a profound way, but it is unclear how often this occurs and to what extent. METHODS: We performed a systematic review to determine the prevalence of changes in personality and behavior in glioma patients. Searches were conducted in PubMed/Medline, PsycINFO, Cochrane, CINAHL and Embase. Based on predetermined in- and exclusion criteria, papers were screened for eligibility. Information on the topics of interest were extracted from the full-text papers. RESULTS: The search yielded 9895 papers, of which 18 were found to be eligible; 9 qualitative and 9 quantitative studies. The reported prevalence rates of changes in personality and/or behavior varied from 8%-67% in glioma patients, and was 100% in a case series with bilateral gliomas. Moreover, these changes were associated with distress and a lower quality of life of patients as well as informal caregivers. Methods of measurement of personality and behavioral changes differed considerably, as did the description of these changes. CONCLUSION: To determine the true prevalence of changes in behavior and personality, present but poorly labeled in the reported studies, prospective studies are needed using proper definitions of personality and behavioral changes and validated measurement tools. Ultimately, these findings may result in improved supportive care of both patients and caregivers, during the disease trajectory.
BACKGROUND: Gliomas are rare, with a dismal outcome and an obvious impact on quality of life, because of neurological, physical and cognitive problems, as well as personality and behavioral changes. These latter changes may affect the lives of both patients and their relatives in a profound way, but it is unclear how often this occurs and to what extent. METHODS: We performed a systematic review to determine the prevalence of changes in personality and behavior in glioma patients. Searches were conducted in PubMed/Medline, PsycINFO, Cochrane, CINAHL and Embase. Based on predetermined in- and exclusion criteria, papers were screened for eligibility. Information on the topics of interest were extracted from the full-text papers. RESULTS: The search yielded 9895 papers, of which 18 were found to be eligible; 9 qualitative and 9 quantitative studies. The reported prevalence rates of changes in personality and/or behavior varied from 8%-67% in glioma patients, and was 100% in a case series with bilateral gliomas. Moreover, these changes were associated with distress and a lower quality of life of patients as well as informal caregivers. Methods of measurement of personality and behavioral changes differed considerably, as did the description of these changes. CONCLUSION: To determine the true prevalence of changes in behavior and personality, present but poorly labeled in the reported studies, prospective studies are needed using proper definitions of personality and behavioral changes and validated measurement tools. Ultimately, these findings may result in improved supportive care of both patients and caregivers, during the disease trajectory.
Authors: Paula R Sherwood; Barbara A Given; Charles W Given; Rachel F Schiffman; Daniel L Murman; Alexander von Eye; Mary Lovely; Lisa R Rogers; Sandy Remer Journal: J Nurs Scholarsh Date: 2007 Impact factor: 3.176
Authors: Hanneke Zwinkels; Linda Dirven; Helen J Bulbeck; Robin Grant; Esther J J Habets; Johan A F Koekkoek; Ingela Oberg; Kathy Oliver; Andrea Pace; Alasdair G Rooney; Maaike J Vos; Martin J B Taphoorn Journal: Neurooncol Pract Date: 2021-07-06