Literature DB >> 3138576

Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons.

M D Majewska1, J M Mienville, S Vicini.   

Abstract

Our earlier biochemical studies suggested that the neurosteroid pregnenolone sulfate (PS) may reduce gamma-aminobutyric acid (GABA) action at the Cl- channel associated with GABAA receptors. In the present electrophysiological study the interaction of PS with the GABAA receptor was tested, using whole-cell voltage-clamp recordings from isolated cerebral cortical neurons of neonatal rats. At micromolar concentrations PS reversibly inhibited GABA-induced current, behaving as an allosteric receptor antagonist.

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Year:  1988        PMID： 3138576     DOI： 10.1016/0304-3940(88)90202-9

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  54 in total

1.  Pregnenolone sulfate and cortisol induce secretion of acyl-CoA-binding protein and its conversion into endozepines from astrocytes.

Authors:  William F Loomis; M Margarita Behrens; Megan E Williams; Christophe Anjard
Journal:  J Biol Chem       Date:  2010-05-07       Impact factor: 5.157

2.  Inhibition of the GABAA Receptor by Sulfated Neurosteroids: A Mechanistic Comparison Study between Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate.

Authors:  Divya Sachidanandan; Amal Kanti Bera
Journal:  J Mol Neurosci       Date:  2015-03-01       Impact factor: 3.444

Review 3.  Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.

Authors:  Jeffrey A Lieberman; Frank P Bymaster; Herbert Y Meltzer; Ariel Y Deutch; Gary E Duncan; Christine E Marx; June R Aprille; Donard S Dwyer; Xin-Min Li; Sahebarao P Mahadik; Ronald S Duman; Joseph H Porter; Josephine S Modica-Napolitano; Samuel S Newton; John G Csernansky
Journal:  Pharmacol Rev       Date:  2008-09       Impact factor: 25.468

Review 4.  The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes.

Authors:  W Hevers; H Lüddens
Journal:  Mol Neurobiol       Date:  1998-08       Impact factor: 5.590

5.  Interaction among alfaxalone, pregnenolone sulfate, and two GABAA agonists on hippocampal slices.

Authors:  S SanMartin; F Andrés-Trelles; L Menendez; A Meana; A Hidalgo; A Baamonde
Journal:  Cell Mol Neurobiol       Date:  1996-06       Impact factor: 5.046

6.  Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current.

Authors:  Lawrence N Eisenman; Yejun He; Christopher Fields; Charles F Zorumski; Steven Mennerick
Journal:  J Physiol       Date:  2003-08-01       Impact factor: 5.182

7.  Modulatory effect of neurosteroids in haloperidol-induced vacuous chewing movements and related behaviors.

Authors:  Mahendra Bishnoi; Kanwaljit Chopra; Shrinivas K Kulkarni
Journal:  Psychopharmacology (Berl)       Date:  2007-10-23       Impact factor: 4.530

8.  Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors.

Authors:  N Brown; J Kerby; T P Bonnert; P J Whiting; K A Wafford
Journal:  Br J Pharmacol       Date:  2002-08       Impact factor: 8.739

Review 9.  Pregnenolone sulfate as a modulator of synaptic plasticity.

Authors:  Conor C Smith; Terrell T Gibbs; David H Farb
Journal:  Psychopharmacology (Berl)       Date:  2014-07-06       Impact factor: 4.530

10.  Delta subunit inhibits neurosteroid modulation of GABAA receptors.

Authors:  W J Zhu; J F Wang; K E Krueger; S Vicini
Journal:  J Neurosci       Date:  1996-11-01       Impact factor: 6.167
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