Pedro Delgado-Floody1, Cristian Álvarez2, Eduardo Lusa Cadore3, Marcelo Flores-Opazo4, Felipe Caamaño-Navarrete5, Mikel Izquierdo6. 1. Department of Physical Education, Sport and Recreation, Universidad de La Frontera, Chile. 2. Quality of Life and Wellness Research Group, Department of Physical Activity Sciences, Universidad de Los Lagos, Chile. 3. Exercise Research Laboratory, Physical Education School, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. 4. Laboratorio de Ciencias del Ejercicio y el Movimiento, Escuela de Kinesiología, Universidad FInis Terrae, Chile. 5. Faculty of Education, Universidad Católica de Temuco, Chile. 6. Grupo GICAEDS, Programa de Cultura Física, Deporte y Recreación, Universidad Santo Tomás, Bogotá, Colombia; Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad Pública de Navarra (UPNA), IDISNA, Pamplona, Navarra, Spain; CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: mikel.izquierdo@gmail.com.
Abstract
BACKGROUND AND AIMS: Resistant training (RT) improves health markers in obesity, but its effects in morbid obesity are unknown. We aimed to determine the effects of a RT-program in preventing/attenuating the metabolic syndrome (MetS) in patients with morbid obesity. A second aim was to report the interindividual variability in terms of improvements in MetS markers and other related co-variables. METHODS AND RESULTS:Twenty-one adults with obesity or morbid obesity were divided into two groups based on body mass index (BMI): a control obesity (CO, n = 7, BMI ≥35 < 40.0 kg/m2) and a morbid obese group (MO, n = 14, BMI ≥40 kg/m2). Participants completed a 20-week RT-program (3 sessions/week, 4-8 exercise) using free weights. Participants were assessed for MetS markers (waist circumference, systolic and diastolic blood pressure [BP], fasting glucose, high-density lipoproteins, and triglycerides) and other co-variables (total cholesterol, low-density lipoprotein, one-maximum repetition of biceps curl, and handgrip strength, 6 min walking test). Significant reductions in MetS markers were observed in both CO and MO groups (P < 0.05 to P < 0.0001), but significant reductions in diastolic BP and increases in HDL-C were noted only in the MO group (P < 0.0001). Changes in waist circumference, and systolic and diastolic BP were significantly greater only in the MO group (P < 0.001), but the CO group presented a greater fasting glucose decreases (P < 0.0001). The prevalence of non-responders between CO and MO groups was similar in the MetS outcomes. CONCLUSIONS: RT promotes greater improvements in overall MetS outcomes waist circumference, BP, and plasma triglycerides in patients with morbid obesity than in obese peers, with no overall differences in the prevalence of non-responders. CLINICAL TRIAL NUMBER: NCT03921853 at www.clinicaltrials.gov.
RCT Entities:
BACKGROUND AND AIMS: Resistant training (RT) improves health markers in obesity, but its effects in morbid obesity are unknown. We aimed to determine the effects of a RT-program in preventing/attenuating the metabolic syndrome (MetS) in patients with morbid obesity. A second aim was to report the interindividual variability in terms of improvements in MetS markers and other related co-variables. METHODS AND RESULTS: Twenty-one adults with obesity or morbid obesity were divided into two groups based on body mass index (BMI): a control obesity (CO, n = 7, BMI ≥35 < 40.0 kg/m2) and a morbid obese group (MO, n = 14, BMI ≥40 kg/m2). Participants completed a 20-week RT-program (3 sessions/week, 4-8 exercise) using free weights. Participants were assessed for MetS markers (waist circumference, systolic and diastolic blood pressure [BP], fasting glucose, high-density lipoproteins, and triglycerides) and other co-variables (total cholesterol, low-density lipoprotein, one-maximum repetition of biceps curl, and handgrip strength, 6 min walking test). Significant reductions in MetS markers were observed in both CO and MO groups (P < 0.05 to P < 0.0001), but significant reductions in diastolic BP and increases in HDL-C were noted only in the MO group (P < 0.0001). Changes in waist circumference, and systolic and diastolic BP were significantly greater only in the MO group (P < 0.001), but the CO group presented a greater fasting glucose decreases (P < 0.0001). The prevalence of non-responders between CO and MO groups was similar in the MetS outcomes. CONCLUSIONS: RT promotes greater improvements in overall MetS outcomes waist circumference, BP, and plasma triglycerides in patients with morbid obesity than in obese peers, with no overall differences in the prevalence of non-responders. CLINICAL TRIAL NUMBER: NCT03921853 at www.clinicaltrials.gov.
Authors: David C Andrade; Marcelo Flores-Opazo; Luis Peñailillo; Pedro Delgado-Floody; Johnattan Cano-Montoya; Jaime A Vásquez-Gómez; Cristian Alvarez Journal: J Clin Med Date: 2021-11-27 Impact factor: 4.241
Authors: Pedro Delgado-Floody; Luis Chirosa-Ríos; Felipe Caamaño-Navarrete; Pablo Valdés-Badilla; Tomás Herrera-Valenzuela; Matías Monsalves-Álvarez; Cristian Núñez-Espinosa; Mauricio Castro-Sepulveda; Eduardo Guzmán-Muñoz; David C Andrade; Cristian Álvarez Journal: Front Physiol Date: 2022-09-23 Impact factor: 4.755
Authors: Pedro Delgado-Floody; Mikel Izquierdo; Robinson Ramírez-Vélez; Felipe Caamaño-Navarrete; Roberto Moris; Daniel Jerez-Mayorga; David C Andrade; Cristian Álvarez Journal: Front Physiol Date: 2020-10-19 Impact factor: 4.566
Authors: Pedro Delgado-Floody; Pedro Ángel Latorre-Román; Daniel Jerez-Mayorga; Felipe Caamaño-Navarrete; Johnattan Cano-Montoya; José Alberto Laredo-Aguilera; Juan Manuel Carmona-Torres; Ana Isabel Cobo-Cuenca; Diana P Pozuelo-Carrascosa; Cristian Álvarez Journal: Int J Environ Res Public Health Date: 2020-09-18 Impact factor: 3.390