Meriem Koual1, German Cano-Sancho2, Anne-Sophie Bats1, Céline Tomkiewicz3, Yael Kaddouch-Amar3, Nathalie Douay-Hauser1, Charlotte Ngo4, Hélène Bonsang4, Myriam Deloménie4, Fabrice Lecuru1, Bruno Le Bizec2, Philippe Marchand2, Jeremie Botton5, Robert Barouki1, Jean-Philippe Antignac2, Xavier Coumoul6. 1. INSERM UMR-S 1124, 45 rue des Saints-Pères, 75006 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Service de Chirurgie Cancérologique Gynécologique et du Sein, Paris, France; Université de Paris, 45 rue des Saints-Pères, 75006 Paris, France. 2. LABERCA, Oniris, INRA, Université Bretagne-Loire, 44307 Nantes, France. 3. INSERM UMR-S 1124, 45 rue des Saints-Pères, 75006 Paris, France; Université de Paris, 45 rue des Saints-Pères, 75006 Paris, France. 4. Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Service de Chirurgie Cancérologique Gynécologique et du Sein, Paris, France; Université de Paris, 45 rue des Saints-Pères, 75006 Paris, France. 5. Faculty of Pharmacy, Univ. Paris-Sud, Université Paris-Saclay, F-92296 Châtenay-Malabry, France. 6. INSERM UMR-S 1124, 45 rue des Saints-Pères, 75006 Paris, France; Université de Paris, 45 rue des Saints-Pères, 75006 Paris, France. Electronic address: xavier.coumoul@parisdescartes.fr.
Abstract
BACKGROUND: Breast cancer (BC) is a major public health concern with over 2 million new cases diagnosed and over 600,000 deaths in 2018 in women worldwide. When distant metastases are present at diagnosis, the 5-year survival rate is only 26%. Recent studies have suggested that persistent organic pollutants (POPs) that accumulate in adipose tissue (AT) can influence tumor phenotype and stimulate cellular processes important for metastasis such as invasion. We, therefore, tested the hypothesis that POP exposure is associated with BC metastasis. METHODS: We conducted an exploratory case-control study in which the concentrations of 49 POPs were measured in both AT and serum samples from BC patients, with or without lymph node metastasis, who underwent partial or total mastectomies, lymph node biopsies and sampling of the adipocytic tumor microenvironment. Adjusted, unconditional logistic models were used to study the associations between the POP concentrations and the risk of metastasis and other hallmarks of cancer aggressiveness. RESULTS: 2.3.7.8-TCDD concentrations in AT are positively associated with the risk of metastasis in 43 patients who have BMIs equal or higher than 25 kg/m2 (odds ratio: 4.48 (1.32-20.71)). Furthermore, the concentrations of 2.3.7.8-TCDD and two coplanar PCBs (77&169) in AT also were positively associated with the risk of lymph node metastasis and the tumor size. CONCLUSION: Our study suggests that 2.3.7.8-TCDD and some PCBs contribute to the development of tumor metastasis and other hallmarks of cancer aggressiveness. While these results should be considered with caution, this is the first study to identify such potential risk factors. Larger longitudinal studies are necessary to confirm our results. Clinical Trial Protocol Record: 2013-A00663-42.
BACKGROUND:Breast cancer (BC) is a major public health concern with over 2 million new cases diagnosed and over 600,000 deaths in 2018 in women worldwide. When distant metastases are present at diagnosis, the 5-year survival rate is only 26%. Recent studies have suggested that persistent organic pollutants (POPs) that accumulate in adipose tissue (AT) can influence tumor phenotype and stimulate cellular processes important for metastasis such as invasion. We, therefore, tested the hypothesis that POP exposure is associated with BC metastasis. METHODS: We conducted an exploratory case-control study in which the concentrations of 49 POPs were measured in both AT and serum samples from BC patients, with or without lymph node metastasis, who underwent partial or total mastectomies, lymph node biopsies and sampling of the adipocytic tumor microenvironment. Adjusted, unconditional logistic models were used to study the associations between the POP concentrations and the risk of metastasis and other hallmarks of cancer aggressiveness. RESULTS: 2.3.7.8-TCDD concentrations in AT are positively associated with the risk of metastasis in 43 patients who have BMIs equal or higher than 25 kg/m2 (odds ratio: 4.48 (1.32-20.71)). Furthermore, the concentrations of 2.3.7.8-TCDD and two coplanar PCBs (77&169) in AT also were positively associated with the risk of lymph node metastasis and the tumor size. CONCLUSION: Our study suggests that 2.3.7.8-TCDD and some PCBs contribute to the development of tumor metastasis and other hallmarks of cancer aggressiveness. While these results should be considered with caution, this is the first study to identify such potential risk factors. Larger longitudinal studies are necessary to confirm our results. Clinical Trial Protocol Record: 2013-A00663-42.
Authors: Yuan Tian; Wei Gui; Bipin Rimal; Imhoi Koo; Philip B Smith; Robert G Nichols; Jingwei Cai; Qing Liu; Andrew D Patterson Journal: Gut Microbes Date: 2020-11-09
Authors: Meriem Koual; Céline Tomkiewicz; Ida Chiara Guerrera; David Sherr; Robert Barouki; Xavier Coumoul Journal: Environ Health Perspect Date: 2021-03-08 Impact factor: 9.031
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