Jessica L Petrick1, Britt W Jensen2, Thorkild I A Sørensen3,4, Michael B Cook1, Jennifer L Baker2,3. 1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. 2. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. 3. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 4. Section of Epidemiology, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Abstract
OBJECTIVE: Esophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) are among the most rapidly increasing cancers in Western countries. Elevated BMI in adulthood is a known risk factor, but associations in early life are unclear. METHODS: This study assessed weight change between childhood and early adulthood in relation to EA/GCA. Measured weights and heights during childhood (7-13 years) and early adulthood (17-26 years) were available for 64,695 young men from the Copenhagen School Health Records Register and the Danish Conscription Database. Individuals were categorized as having normal weight or overweight. Linkage with the Danish Cancer Registry identified 275 EA/GCA cases. Hazard ratios (HR) and 95% CI were estimated using Cox proportional hazards regression. RESULTS: The risk of EA/GCA was 2.5 times higher in men who were first classified as having overweight at age 7 (HR = 2.49; 95% CI: 1.50-4.14) compared with men who were never classified as having overweight. Men who had persistent overweight at ages 7 and 13 and in early adulthood had an EA/GCA risk that was 3.2 times higher (HR = 3.18; 95% CI: 1.57-6.44). However, there was little evidence of increased EA/GCA risk for men with overweight during childhood and subsequent remittance by early adulthood. CONCLUSIONS: Persistent overweight in early life is associated with increased EA/GCA risk, which declines if body weight is reduced.
OBJECTIVE: Esophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) are among the most rapidly increasing cancers in Western countries. Elevated BMI in adulthood is a known risk factor, but associations in early life are unclear. METHODS: This study assessed weight change between childhood and early adulthood in relation to EA/GCA. Measured weights and heights during childhood (7-13 years) and early adulthood (17-26 years) were available for 64,695 young men from the Copenhagen School Health Records Register and the Danish Conscription Database. Individuals were categorized as having normal weight or overweight. Linkage with the Danish Cancer Registry identified 275 EA/GCA cases. Hazard ratios (HR) and 95% CI were estimated using Cox proportional hazards regression. RESULTS: The risk of EA/GCA was 2.5 times higher in men who were first classified as having overweight at age 7 (HR = 2.49; 95% CI: 1.50-4.14) compared with men who were never classified as having overweight. Men who had persistent overweight at ages 7 and 13 and in early adulthood had an EA/GCA risk that was 3.2 times higher (HR = 3.18; 95% CI: 1.57-6.44). However, there was little evidence of increased EA/GCA risk for men with overweight during childhood and subsequent remittance by early adulthood. CONCLUSIONS: Persistent overweight in early life is associated with increased EA/GCA risk, which declines if body weight is reduced.
Authors: K K Cheng; L Sharp; P A McKinney; R F Logan; C E Chilvers; P Cook-Mozaffari; A Ahmed; N E Day Journal: Br J Cancer Date: 2000-07 Impact factor: 7.640
Authors: Michael B Cook; Douglas A Corley; Liam J Murray; Linda M Liao; Farin Kamangar; Weimin Ye; Marilie D Gammon; Harvey A Risch; Alan G Casson; Neal D Freedman; Wong-Ho Chow; Anna H Wu; Leslie Bernstein; Olof Nyrén; Nirmala Pandeya; David C Whiteman; Thomas L Vaughan Journal: PLoS One Date: 2014-07-30 Impact factor: 3.240
Authors: Jonas F Ludvigsson; Siri E Håberg; Gun Peggy Knudsen; Pierre Lafolie; Helga Zoega; Catharina Sarkkola; Stephanie von Kraemer; Elisabete Weiderpass; Mette Nørgaard Journal: Clin Epidemiol Date: 2015-11-23 Impact factor: 4.790
Authors: Jessica K Sheth Bhutada; Amie E Hwang; Lihua Liu; Kai-Ya Tsai; Dennis Deapen; David R Freyer Journal: Cancers (Basel) Date: 2022-10-08 Impact factor: 6.575
Authors: Joel Nuotio; Tomi T Laitinen; Alan R Sinaiko; Jessica G Woo; Elaine M Urbina; David R Jacobs; Julia Steinberger; Ronald J Prineas; Matthew A Sabin; David P Burgner; Heikki Minn; Trudy L Burns; Lydia A Bazzano; Alison J Venn; Jorma S A Viikari; Nina Hutri-Kähönen; Stephen R Daniels; Olli T Raitakari; Costan G Magnussen; Markus Juonala; Terence Dwyer Journal: Int J Obes (Lond) Date: 2021-11-02 Impact factor: 5.095