Literature DB >> 3137987

Changes in choline acetyltransferase activity of rat tissues during Chagas' disease.

C R Machado1, M V Gomez, A B Machado.   

Abstract

1. The activity of choline acetyltransferase (CAT) measured by a radiolabeling method was significantly reduced in the heart, submandibular gland and esophagus of rats 20 days after inoculation with Trypanosoma cruzi (Y strain). 2. Normal enzyme activity was recovered in all these organs 100 days after inoculation. 3. In the transverse colon, no change, 30% reduction and normal activity were found at days 20, 100 and 430 of infection, respectively. 4. The data indicate recovery of parasympathetic function in experimental Chagas' disease. Axonal regrowth and sprouting are discussed as possible candidates for the recovery mechanisms.

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Year:  1987        PMID: 3137987

Source DB:  PubMed          Journal:  Braz J Med Biol Res        ISSN: 0100-879X            Impact factor:   2.590


  7 in total

Review 1.  Role of autoantibodies in the physiopathology of Chagas' disease.

Authors:  Emiliano Horacio Medei; José Hamilton Matheus Nascimento; Roberto Coury Pedrosa; Antônio Carlos Campos de Carvalho
Journal:  Arq Bras Cardiol       Date:  2008-10       Impact factor: 2.000

2.  A trypanosomal protein synergizes with the cytokines ciliary neurotrophic factor and leukemia inhibitory factor to prevent apoptosis of neuronal cells.

Authors:  M V Chuenkova; M A Pereira
Journal:  Mol Biol Cell       Date:  2000-04       Impact factor: 4.138

3.  Trypanosoma cruzi-Derived Neurotrophic Factor: Role in Neural Repair and Neuroprotection.

Authors:  Marina V Chuenkova; Mercio Pereiraperrin
Journal:  J Neuroparasitology       Date:  2010-07-26

4.  Trypanosoma cruzi infection in rats induced early lesion of the heart noradrenergic nerve terminals by a complement-independent mechanism.

Authors:  C R Machado; D A de Oliveira; M J Magalhaes; E M Carvalho; F J Ramalho-Pinto
Journal:  J Neural Transm Gen Sect       Date:  1994

5.  Chagas' disease parasite-derived neurotrophic factor activates cholinergic gene expression in neuronal PC12 cells.

Authors:  Nsikan Akpan; Kacey Caradonna; Marina V Chuenkova; Mercio PereiraPerrin
Journal:  Brain Res       Date:  2008-04-10       Impact factor: 3.252

6.  Renin angiotensin system molecules and nitric oxide local interactions in the adrenal gland of Trypanosoma cruzi infected rats.

Authors:  Aline Silva Miranda; Elizabeth R S Camargos; Lucas Alexandre Santos Marzano; Alessandra Cristina Santos Marzano; Bruna da Silva Oliveira; Rodrigo Novaes Ferreira; Patrícia Massara Martinelli; Antônio Lúcio Teixeira; Milene Alvarenga Rachid; Ana Cristina Simões E Silva
Journal:  Parasitol Res       Date:  2019-12-01       Impact factor: 2.289

7.  Partial, selective survival of nitrergic neurons in chagasic megacolon.

Authors:  Samir Jabari; Alexandre B M da Silveira; Enio C de Oliveira; Salustiano G Neto; Karl Quint; Winfried Neuhuber; Axel Brehmer
Journal:  Histochem Cell Biol       Date:  2010-12-24       Impact factor: 4.304

  7 in total

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