Elena Myasoedova1, John M Davis2, Eric L Matteson3, Sara J Achenbach4, Soko Setoguchi5, Shannon M Dunlay6, Veronique L Roger7, Sherine E Gabriel5, Cynthia S Crowson8. 1. Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: myasoedova.elena@mayo.edu. 2. Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. 3. Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. 4. Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. 5. Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. 6. Department of Cardiovascular Disease, Division of Circulatory Failure, Mayo Clinic, Rochester, MN, USA. 7. Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Cardiovascular Disease, Division of Circulatory Failure, Mayo Clinic, Rochester, MN, USA. 8. Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA; Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Abstract
OBJECTIVE: To compare the frequency of and trends in hospitalizations after heart failure (HF) diagnosis in patients with and without rheumatoid arthritis (RA) during 1987-2015. METHODS: The study included a retrospectively identified population-based cohort of patients with incident HF and prior RA (age≥18 years, 1987 ACR criteria) and a cohort of incident HF patients without RA matched 3:1 on age, sex, and year of HF diagnosis. Hospitalizations at the time of HF diagnosis were excluded. All subjects were followed until death, migration, or 12/31/2015. RESULTS: The study included 212 patients with RA (mean age at HF diagnosis 78.3 years; 68% female) and 636 non-RA patients (mean age at HF diagnosis 78.6 years; 68% female). The hospitalization rate after HF diagnosis was higher in RA vs non-RA (rate ratio [RR] 1.17; 95%CI 1.08-1.26). Hospitalization rates in both groups have been declining since 2005 and the difference between patients with and without RA may be decreasing after 2010. The magnitude of the increase was similar in both sexes and across all ages. Patients with RA were more likely to be hospitalized for non-cardiovascular causes (RR 1.26; 95%CI 1.14-1.39), but not for HF or other cardiovascular causes compared to non-RA patients. CONCLUSIONS: The hospitalization rate following HF diagnosis was higher in RA versus non-RA patients regardless of sex and age. Increased hospitalization risk in patients with RA was driven by increased rates of non-cardiovascular hospitalization.
OBJECTIVE: To compare the frequency of and trends in hospitalizations after heart failure (HF) diagnosis in patients with and without rheumatoid arthritis (RA) during 1987-2015. METHODS: The study included a retrospectively identified population-based cohort of patients with incident HF and prior RA (age≥18 years, 1987 ACR criteria) and a cohort of incident HF patients without RA matched 3:1 on age, sex, and year of HF diagnosis. Hospitalizations at the time of HF diagnosis were excluded. All subjects were followed until death, migration, or 12/31/2015. RESULTS: The study included 212 patients with RA (mean age at HF diagnosis 78.3 years; 68% female) and 636 non-RApatients (mean age at HF diagnosis 78.6 years; 68% female). The hospitalization rate after HF diagnosis was higher in RA vs non-RA (rate ratio [RR] 1.17; 95%CI 1.08-1.26). Hospitalization rates in both groups have been declining since 2005 and the difference between patients with and without RA may be decreasing after 2010. The magnitude of the increase was similar in both sexes and across all ages. Patients with RA were more likely to be hospitalized for non-cardiovascular causes (RR 1.26; 95%CI 1.14-1.39), but not for HF or other cardiovascular causes compared to non-RApatients. CONCLUSIONS: The hospitalization rate following HF diagnosis was higher in RA versus non-RApatients regardless of sex and age. Increased hospitalization risk in patients with RA was driven by increased rates of non-cardiovascular hospitalization.
Authors: Daniel H Solomon; Jeremy A Rassen; Bindee Kuriya; Lang Chen; Leslie R Harrold; David J Graham; James D Lewis; Joyce Lii; Liyan Liu; Marie R Griffin; J R Curtis Journal: Ann Rheum Dis Date: 2012-11-15 Impact factor: 19.103
Authors: Shannon M Dunlay; Margaret M Redfield; Susan A Weston; Terry M Therneau; Kirsten Hall Long; Nilay D Shah; Véronique L Roger Journal: J Am Coll Cardiol Date: 2009-10-27 Impact factor: 24.094