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Literature DB >> 31376067

Sleep as a Therapeutic Target in the Aging Brain.

Thierno M Bah¹, James Goodman¹, Jeffrey J Iliff^2,3,4,5,6.

Abstract

Sleep is a behavioral phenomenon conserved among mammals and some invertebrates, yet the biological functions of sleep are still being elucidated. In humans, sleep time becomes shorter, more fragmented, and of poorer quality with advancing age. Epidemiologically, the development of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's disease is associated with pronounced sleep disruption, whereas emerging mechanistic studies suggest that sleep disruption may be causally linked to neurodegenerative pathology, suggesting that sleep may represent a key therapeutic target in the prevention of these conditions. In this review, we discuss the physiology of sleep, the pathophysiology of neurodegenerative disease, and the current literature supporting the relationship between sleep, aging, and neurodegenerative disease.

Entities: Disease Species

Keywords: Alzheimer’s disease; Sleep; aging; cognitive decline; dementia; treatment.

Mesh：

Year: 2019 PMID： 31376067 PMCID： PMC6694322 DOI： 10.1007/s13311-019-00769-6

Source DB: PubMed Journal: Neurotherapeutics ISSN： 1878-7479 Impact factor: 7.620

210 in total

Review 1. Sleep and aging: prevalence of disturbed sleep and treatment considerations in older adults.

Authors: Sonia Ancoli-Israel
Journal: J Clin Psychiatry Date: 2005 Impact factor: 4.384

2. Sleep Dysfunction in Alzheimer's Disease and Other Dementias.

Authors: Susan M. McCurry; Sonia Ancoli-Israel
Journal: Curr Treat Options Neurol Date: 2003-05 Impact factor: 3.598

Review 3. Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration.

Authors: Giulio Tononi; Chiara Cirelli
Journal: Neuron Date: 2014-01-08 Impact factor: 17.173

4. Affective symptoms associated with the onset of major depression in the community: findings from the US National Institute of Mental Health Epidemiologic Catchment Area Program.

Authors: A Dryman; W W Eaton
Journal: Acta Psychiatr Scand Date: 1991-07 Impact factor: 6.392

5. Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder.

Authors: B F Boeve; M H Silber; T J Ferman; S C Lin; E E Benarroch; A M Schmeichel; J E Ahlskog; R J Caselli; S Jacobson; M Sabbagh; C Adler; B Woodruff; T G Beach; A Iranzo; E Gelpi; J Santamaria; E Tolosa; C Singer; D C Mash; C Luca; I Arnulf; C Duyckaerts; C H Schenck; M W Mahowald; Y Dauvilliers; N R Graff-Radford; Z K Wszolek; J E Parisi; B Dugger; M E Murray; D W Dickson
Journal: Sleep Med Date: 2013-03-07 Impact factor: 3.492

6. Sleep quality and preclinical Alzheimer disease.

Authors: Yo-El S Ju; Jennifer S McLeland; Cristina D Toedebusch; Chengjie Xiong; Anne M Fagan; Stephen P Duntley; John C Morris; David M Holtzman
Journal: JAMA Neurol Date: 2013-05 Impact factor: 18.302

Review 7. Sleep-dependent memory triage: evolving generalization through selective processing.

Authors: Robert Stickgold; Matthew P Walker
Journal: Nat Neurosci Date: 2013-01-28 Impact factor: 24.884

8. Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study.

Authors: Pieter Jelle Visser; Frans Verhey; Dirk L Knol; Philip Scheltens; Lars-Olof Wahlund; Yvonne Freund-Levi; Magda Tsolaki; Lennart Minthon; Asa K Wallin; Harald Hampel; Katharina Bürger; Tuula Pirttila; Hilkka Soininen; Marcel Olde Rikkert; Marcel M Verbeek; Luiza Spiru; Kaj Blennow
Journal: Lancet Neurol Date: 2009-06-10 Impact factor: 44.182

Sleep as a Therapeutic Target in the Aging Brain.

Review 1. Sleep and aging: prevalence of disturbed sleep and treatment considerations in older adults.

2. Sleep Dysfunction in Alzheimer's Disease and Other Dementias.

Review 3. Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration.

4. Affective symptoms associated with the onset of major depression in the community: findings from the US National Institute of Mental Health Epidemiologic Catchment Area Program.

5. Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder.

6. Sleep quality and preclinical Alzheimer disease.

Review 7. Sleep-dependent memory triage: evolving generalization through selective processing.

8. Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study.

9. The effects of age, sex, ethnicity, and sleep-disordered breathing on sleep architecture.

10. Sleep disturbance in mental health problems and neurodegenerative disease.

1. Neurotherapeutics of the Aging Brain: Complexity Meets Complexity.

Review 2. The glymphatic system: implications for drugs for central nervous system diseases.

3. Preventive Measures against the Development of Dementia in Old Age.

4. An investigation of cannabis use for insomnia in depression and anxiety in a naturalistic sample.

Review 5. Bidirectional Association Between Sleep and Brain Atrophy in Aging.