Min-Sun Kim1, Eun-Kyung Kim1, Joon Young Choi2, Jae K Oh3, Sung-A Chang4. 1. Division of Cardiology, Department of Medicine, Samsung Medical Center, Heart Vascular and Stroke Institute Imaging Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. 2. Department of Nuclear Medicine and Molecular Imaging, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 3. Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA. 4. Division of Cardiology, Department of Medicine, Samsung Medical Center, Heart Vascular and Stroke Institute Imaging Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. elisabet.chang@gmail.com.
Abstract
Identification of the etiology of pericardial disease is challenging because the accessibility to pericardial fluid and tissue is limited and there is a relatively low yield of fluid and tissue analysis. Pericardial disease is associated with various systemic diseases and is frequently a first manifestation of other systemic diseases. Detecting the cause of pericarditis and minimizing the subsequent inflammatory process can possibly prevent long-term complications. PURPOSE OF REVIEW: To review the clinical utility of [18F]-2-deoxy-2-fluoro-D-glucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) in the diagnosis and treatment of pericardial disease. RECENT FINDINGS: [18F]FDG-PET/CT can visualize the hypermetabolic tissues of both malignancy and inflammation. Distribution of [18F]FDG-PET/CT uptake can provide information for neoplastic disease. If malignancy is ruled out, high uptake of pericardium is associated with active inflammation of the pericardium, and thus response to anti-inflammatory agents can also be predicted with [18F]FDG-PET/CT imaging. [18F]FDG-PET/CT can be helpful for diagnosing and establishing prognosis and for planning for anti-inflammatory treatment in pericardial disease.
Identification of the etiology of pericardial disease is challenging because the accessibility to pericardial fluid and tissue is limited and there is a relatively low yield of fluid and tissue analysis. Pericardial disease is associated with various systemic diseases and is frequently a first manifestation of other systemic diseases. Detecting the cause of pericarditis and minimizing the subsequent inflammatory process can possibly prevent long-term complications. PURPOSE OF REVIEW: To review the clinical utility of [18F]-2-deoxy-2-fluoro-D-glucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) in the diagnosis and treatment of pericardial disease. RECENT FINDINGS: [18F]FDG-PET/CT can visualize the hypermetabolic tissues of both malignancy and inflammation. Distribution of [18F]FDG-PET/CT uptake can provide information for neoplastic disease. If malignancy is ruled out, high uptake of pericardium is associated with active inflammation of the pericardium, and thus response to anti-inflammatory agents can also be predicted with [18F]FDG-PET/CT imaging. [18F]FDG-PET/CT can be helpful for diagnosing and establishing prognosis and for planning for anti-inflammatory treatment in pericardial disease.
Authors: John H Haley; A Jamil Tajik; Gordon K Danielson; Hartzell V Schaff; Sharon L Mulvagh; Jae K Oh Journal: J Am Coll Cardiol Date: 2004-01-21 Impact factor: 24.094
Authors: Stefan C Bertog; Senthil K Thambidorai; Kapil Parakh; Paul Schoenhagen; Volkan Ozduran; Penny L Houghtaling; Bruce W Lytle; Eugene H Blackstone; Michael S Lauer; Allan L Klein Journal: J Am Coll Cardiol Date: 2004-04-21 Impact factor: 24.094