Jasmine Yee1, Glen M Davis1, Daniel Hackett1, Jane M Beith2, Nicholas Wilcken3, David Currow4, Jon Emery5, Jane Phillips6, Andrew Martin7, Rina Hui3, Michelle Harrison2, Eva Segelov8, Sharon L Kilbreath9. 1. Faculty of Health Sciences, The University of Sydney, Lidcombe, Australia. 2. The Chris O'Brien Lifehouse, Camperdown, Australia. 3. Crown Princess Mary Cancer Centre, Westmead Hospital, The University of Sydney, Lidcombe, Australia. 4. Faculty of Health Sciences, Flinders University, Daw Park, Australia. 5. General Practice and Primary Care Academic Centre, University of Melbourne, Parkville, Australia; General Practice, University of Western Australia, Crawley, Australia. 6. Faculty of Health, University of Technology Sydney, Ultimo, Australia. 7. Clinical Trials Centre, University of Sydney, Camperdown, Australia. 8. Monash Health and Monash University, Melbourne, Australia. 9. Faculty of Health Sciences, The University of Sydney, Lidcombe, Australia. Electronic address: sharon.kilbreath@sydney.edu.au.
Abstract
CONTEXT: Physical activity for women with early-stage breast cancer is well recognized for managing cancer-related symptoms and improving quality of life. While typically excluded from interventions, women with metastatic breast cancer may also benefit from physical activity. OBJECTIVE: To 1) determine the safety and feasibility of a physical activity program for women with metastatic breast cancer and 2) explore the efficacy of the program. METHODS:Fourteen women with metastatic breast cancer were randomized to either a control group or an 8-week home-based physical activity intervention comprising twice weekly supervised resistance training and an unsupervized walking program. RESULTS: The recruitment rate was 93%. Adherence to the resistance and walking components of the program was 100% and 25%, respectively. No adverse events were reported. When mean change scores from baseline to postintervention were compared, trends in favor of the exercise group over the control group were observed for the Functional Assessment of Chronic Illness Therapy-Fatigue score (+5.6 ± 3.2 vs. -1.8 ± 3.9, respectively), VO2max (+1.6 ml/kg/minute ±1.8 mL/kg/minute vs. -0.2 mL/kg/minute ±0.1 mL/kg/minute, respectively) and six-minute walk test (+40 m ± 23 m vs. -46 m ± 56 m, respectively). CONCLUSION: A partially supervised home-based physical activity program for women with metastatic breast cancer is feasible and safe. The dose of the resistance training component was well tolerated and achievable in this population. In contrast, adherence and compliance to the walking program were poor. Preliminary data suggest a physical activity program, comprising predominantly resistance training, may lead to improvements in physical capacity and may help women to live well with their disease.
RCT Entities:
CONTEXT: Physical activity for women with early-stage breast cancer is well recognized for managing cancer-related symptoms and improving quality of life. While typically excluded from interventions, women with metastatic breast cancer may also benefit from physical activity. OBJECTIVE: To 1) determine the safety and feasibility of a physical activity program for women with metastatic breast cancer and 2) explore the efficacy of the program. METHODS: Fourteen women with metastatic breast cancer were randomized to either a control group or an 8-week home-based physical activity intervention comprising twice weekly supervised resistance training and an unsupervized walking program. RESULTS: The recruitment rate was 93%. Adherence to the resistance and walking components of the program was 100% and 25%, respectively. No adverse events were reported. When mean change scores from baseline to postintervention were compared, trends in favor of the exercise group over the control group were observed for the Functional Assessment of Chronic Illness Therapy-Fatigue score (+5.6 ± 3.2 vs. -1.8 ± 3.9, respectively), VO2max (+1.6 ml/kg/minute ±1.8 mL/kg/minute vs. -0.2 mL/kg/minute ±0.1 mL/kg/minute, respectively) and six-minute walk test (+40 m ± 23 m vs. -46 m ± 56 m, respectively). CONCLUSION: A partially supervised home-based physical activity program for women with metastatic breast cancer is feasible and safe. The dose of the resistance training component was well tolerated and achievable in this population. In contrast, adherence and compliance to the walking program were poor. Preliminary data suggest a physical activity program, comprising predominantly resistance training, may lead to improvements in physical capacity and may help women to live well with their disease.
Authors: Emma J Chapman; Erica Di Martino; Zoe Edwards; Kathryn Black; Matthew Maddocks; Michael I Bennett Journal: Palliat Med Date: 2021-12-14 Impact factor: 4.762
Authors: Sergio Rodríguez-Cañamero; Ana Isabel Cobo-Cuenca; Juan Manuel Carmona-Torres; Diana Patricia Pozuelo-Carrascosa; Esmeralda Santacruz-Salas; Joseba Aingerun Rabanales-Sotos; Tatiana Cuesta-Mateos; José Alberto Laredo-Aguilera Journal: Cancer Med Date: 2022-04-11 Impact factor: 4.711