| Literature DB >> 3137306 |
T J Santoro1, D H Morris, R C Murphy, R C Baker.
Abstract
Eicosanoids have been implicated in the pathogenesis of autoimmune diseases. In this study, peritoneal macrophages from autoimmune-prone mice were examined for their capacity to produce proinflammatory 5-lipoxygenase metabolites. The results indicate that enhanced production of leukotriene C4 is a common feature of murine autoimmunity and suggest further that aberrations in 5-lipoxygenase activity may play a role in the development of lupus.Entities:
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Year: 1988 PMID： 3137306 PMCID： PMC2188998 DOI： 10.1084/jem.168.2.783
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307