Kieran J Marston1,2, Belinda M Brown3,4,5,6, Stephanie R Rainey-Smith4,5,6, Sabine Bird5,6, Linda Wijaya7, Shaun Y M Teo3, Simon M Laws8,9, Ralph N Martins5,6, Jeremiah J Peiffer3,4. 1. Department of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, Perth, WA, 6150, Australia. K.Marston@murdoch.edu.au. 2. Ageing, Cognition and Exercise (ACE) Research Group, Murdoch University, Perth, WA, Australia. K.Marston@murdoch.edu.au. 3. Department of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, Perth, WA, 6150, Australia. 4. Ageing, Cognition and Exercise (ACE) Research Group, Murdoch University, Perth, WA, Australia. 5. Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia. 6. Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, WA, Australia. 7. Department of Psychology, College of Science, Health, Engineering and Education, Murdoch University, Perth, WA, Australia. 8. Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia. 9. School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.
Abstract
INTRODUCTION: There is growing evidence for a preventative effect of resistance training on cognitive decline through physiological mechanisms; yet, the effect of resistance training on resting growth factors and homocysteine levels is incompletely understood. This study aimed to investigate the effect of intense resistance training, for 12 weeks, on changes in peripheral growth factors and homocysteine in late middle-aged adults. METHODS:45 healthy adults were enrolled into the single-site parallel groups' randomized-controlled trial conducted at the Department of Exercise Science, Strength and Conditioning Laboratory, Murdoch University. Participants were allocated to the following conditions: (1) high-load resistance training (n = 14), or (2) moderate-load resistance training (n = 15) twice per week for 12 weeks; or (3) non-exercising control group (n = 16). Data were collected from September 2016 to December 2017. Fasted blood samples were collected at baseline and within 7 days of trial completion for the analysis of resting serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1, vascular endothelial growth factor, and plasma homocysteine levels. RESULTS: No differences in baseline to post-intervention change in serum growth factors or plasma homocysteine levels were observed between groups. A medium effect was calculated for BDNF change within the high-load condition alone (+ 12.9%, g = 0.54). CONCLUSIONS: High-load or moderate-load resistance training twice per week for 12 weeks has no effect on peripheral growth factors or homocysteine in healthy late middle-aged adults. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry: ACTRN12616000690459.
RCT Entities:
INTRODUCTION: There is growing evidence for a preventative effect of resistance training on cognitive decline through physiological mechanisms; yet, the effect of resistance training on resting growth factors and homocysteine levels is incompletely understood. This study aimed to investigate the effect of intense resistance training, for 12 weeks, on changes in peripheral growth factors and homocysteine in late middle-aged adults. METHODS: 45 healthy adults were enrolled into the single-site parallel groups' randomized-controlled trial conducted at the Department of Exercise Science, Strength and Conditioning Laboratory, Murdoch University. Participants were allocated to the following conditions: (1) high-load resistance training (n = 14), or (2) moderate-load resistance training (n = 15) twice per week for 12 weeks; or (3) non-exercising control group (n = 16). Data were collected from September 2016 to December 2017. Fasted blood samples were collected at baseline and within 7 days of trial completion for the analysis of resting serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1, vascular endothelial growth factor, and plasma homocysteine levels. RESULTS: No differences in baseline to post-intervention change in serum growth factors or plasma homocysteine levels were observed between groups. A medium effect was calculated for BDNF change within the high-load condition alone (+ 12.9%, g = 0.54). CONCLUSIONS: High-load or moderate-load resistance training twice per week for 12 weeks has no effect on peripheral growth factors or homocysteine in healthy late middle-aged adults. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry: ACTRN12616000690459.
Entities:
Keywords:
Cognitive decline; Growth factors; Homocysteine; Preventative medicine; Strength training
Authors: Beate E M Zunner; Nadine B Wachsmuth; Max L Eckstein; Lukas Scherl; Janis R Schierbauer; Sandra Haupt; Christian Stumpf; Laura Reusch; Othmar Moser Journal: Int J Mol Sci Date: 2022-03-23 Impact factor: 5.923
Authors: Mariana Toricelli; Arthur Antonio Ruiz Pereira; Guilherme Souza Abrao; Helena Nascimento Malerba; Julia Maia; Hudson Sousa Buck; Tania Araujo Viel Journal: Neural Regen Res Date: 2021-01 Impact factor: 5.135