Literature DB >> 31372681

Tbx3-Mediated Regulation of Cardiac Conduction System Development and Function: Potential Contributions of Alternative RNA Processing.

Brian P Delisle1, Yao Yu2, Pavan Puvvula3, Allison R Hall1, Chad Huff2, Anne M Moon4,5.   

Abstract

In this article, we provide a brief summary of work by us and others to discover the molecular underpinnings of early conduction system development and function. We focus on how the multifunctional protein Tbx3 contributes to acquisition and homeostasis of the tissue-specific properties of the sinoatrial and atrioventricular nodes. We also provide unpublished, preliminary findings supporting the role of Tbx3-regulated alternative RNA processing in the developing conduction system.

Entities:  

Keywords:  Channelopathies; Conduction system; Development; Tbx3

Mesh：

Substances：

Year:  2019        PMID： 31372681     DOI： 10.1007/s00246-019-02166-4

Source DB:  PubMed          Journal:  Pediatr Cardiol        ISSN： 0172-0643            Impact factor:   1.655


  85 in total

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Journal:  Mol Cell       Date:  2010-08-13       Impact factor: 17.970

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Journal:  Genomics       Date:  2005-02       Impact factor: 5.736

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Authors:  Céline Marionneau; Brigitte Couette; Jie Liu; Huiyu Li; Matteo E Mangoni; Joël Nargeot; Ming Lei; Denis Escande; Sophie Demolombe
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10.  Evolution at protein ends: major contribution of alternative transcription initiation and termination to the transcriptome and proteome diversity in mammals.

Authors:  Svetlana A Shabalina; Aleksey Y Ogurtsov; Nikolay A Spiridonov; Eugene V Koonin
Journal:  Nucleic Acids Res       Date:  2014-05-03       Impact factor: 16.971
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