Literature DB >> 3137194

Medullasin induces activated killer cells from human lymphocytes.

Y Aoki1.   

Abstract

Treatment of human lymphocytes with a physiological amount of medullasin, a serine protease found in bone marrow cells, resulted in the induction of activated killer cells which can lyse both natural killer-sensitive and -resistant target cells. The optimum concentration of medullasin was 20 micrograms/ml when lymphocytes were treated with the protease at 37 degrees C for 60 min. Kinetic studies of the induction revealed that the maximum induction was achieved 24 hr after medullasin treatment.

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Year:  1988        PMID： 3137194      PMCID： PMC5917583          DOI： 10.1111/j.1349-7006.1988.tb02223.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  19 in total

1.  Role of medullasin in granulocytes in the development of inflammation. I. Phlogistic activity and the effect on functions of macrophages and granulocytes.

Authors:  Y Aoki; R Machinami
Journal:  Arthritis Rheum       Date:  1983-08

2.  Crystallization and characterization of a new protease in mitochondria of bone marrow cells.

Authors:  Y Aoki
Journal:  J Biol Chem       Date:  1978-03-25       Impact factor: 5.157

3.  Medullasin stimulates the maturation of natural killer cells from human large granular lymphocytes.

Authors:  Y Aoki
Journal:  Jpn J Cancer Res       Date:  1987-01

4.  Medullasin enhances human natural killer cell activity.

Authors:  Y Aoki; M Sumiya; K Oshimi
Journal:  J Clin Invest       Date:  1982-06       Impact factor: 14.808

5.  Induction of NK cell activity against fresh human leukemia in culture with interleukin 2.

Authors:  E Lotzová; C A Savary; R B Herberman
Journal:  J Immunol       Date:  1987-04-15       Impact factor: 5.422

6.  Cytotoxicity of interleukin 2-activated lymphocytes for leukemia and lymphoma cells.

Authors:  K Oshimi; Y Oshimi; M Akutsu; Y Takei; H Saito; M Okada; H Mizoguchi
Journal:  Blood       Date:  1986-10       Impact factor: 22.113

7.  The mechanism of activation of human natural killer cells by medullasin.

Authors:  Y Aoki
Journal:  Jpn J Cancer Res       Date:  1986-10

8.  Lymphokine-activated killer cells. Analysis of progenitors and effectors.

Authors:  J R Ortaldo; A Mason; R Overton
Journal:  J Exp Med       Date:  1986-10-01       Impact factor: 14.307

9.  Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells.

Authors:  E A Grimm; R J Robb; J A Roth; L M Neckers; L B Lachman; D J Wilson; S A Rosenberg
Journal:  J Exp Med       Date:  1983-10-01       Impact factor: 14.307

10.  Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.

Authors:  E A Grimm; A Mazumder; H Z Zhang; S A Rosenberg
Journal:  J Exp Med       Date:  1982-06-01       Impact factor: 14.307
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  2 in total

1.  Induction of activated killer cells from human lymphocytes by medullasin (a serine protease in bone marrow cells).

Authors:  Y Aoki; T Hase; K Oshimi; K Suzuki
Journal:  Immunology       Date:  1992-03       Impact factor: 7.397

2.  Azurocidin induces elastinolytic activity of medullasin.

Authors:  Yosuke Aoki
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2006-11-18       Impact factor: 3.493
  2 in total

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