Literature DB >> 3137081

Effects of indomethacin and diclofenac on cerebral blood flow in hypercapnic conscious rats.

A Quintana1, E Raczka, M A Quintana.   

Abstract

Cerebral blood flow (CBF) was measured in conscious rats treated with indomethacin, diclofenac or the vehicle for indomethacin during hypercapnia of three different degrees. Similar values were found for CBF in rats treated with diclofenac or vehicle and there was a direct correlation between CBF and the arterial blood carbon dioxide values. In contrast, indomethacin completely blocked the increase of CBF during hypercapnia. These results suggest strongly that prostaglandins are not involved in the hypercapnia-induced cerebral vasodilatation.

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Year:  1988        PMID： 3137081     DOI： 10.1016/0014-2999(88)90674-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

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6.  Obligatory Role of EP1 Receptors in the Increase in Cerebral Blood Flow Produced by Hypercapnia in the Mice.

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  6 in total

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