Hwa Sung Lee1, Kwang Jun Oh2, Young Wan Moon3, Yong In4, Han Jun Lee5, Soon Yong Kwon1. 1. Department of Orthopedic Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 2. Department of Orthopedic Surgery, Konkuk University Medical Center, School of Medicine, Konkuk University, Seoul, Republic of Korea. 3. Department of Orthopedic Surgery, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Republic of Korea. 4. Department of Orthopedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 5. Department of Orthopedic Surgery, Chung-Ang University Hospital, School of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Abstract
OBJECTIVE: Collagen disruption is one of the underlying causes of knee pain in patients with osteoarthritis and/or diverse cartilage defects. Atelocollagen is a type of collagen that lacks telopeptides and thus has reduced antigenicity. The intra-articular injection of type I atelocollagen supplements collagen levels in the disrupted articular cartilage. This randomized controlled trial evaluated the effects of the intra-articular injection of atelocollagen for the management of knee pain. DESIGN: Two hundred patients with osteoarthritis, chondromalacia, or other cartilage defects were randomly assigned to receive a 3-mL intra-articular injection of atelocollagen (BioCollagen group) or saline (Placebo group). Clinical improvement was evaluated over a 24-week period using the 100-mm visual analogue scale (VAS), the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), and the 36-item Short-Form Health Survey (SF-36). RESULTS: VAS scores were significantly better in the BioCollagen group as compared with the Placebo group at 24 weeks. More patients in the BioCollagen group reported exceeding 20% and 40% VAS improvements. The WOMAC and SF-36 scores were also significantly improved from baseline after the intra-articular injection of atelocollagen; although, the differences between the BioCollagen and Placebo groups were not significant. There were no unexpected or severe adverse events reported for either group. CONCLUSIONS: The results show that an intra-articular injection of atelocollagen effectively alleviates knee pain, as intended. Therefore, the intra-articular injection of atelocollagen can be considered an alternative solution to controlling knee pain due to osteoarthritis and diverse cartilage defects.
OBJECTIVE: Collagen disruption is one of the underlying causes of knee pain in patients with osteoarthritis and/or diverse cartilage defects. Atelocollagen is a type of collagen that lacks telopeptides and thus has reduced antigenicity. The intra-articular injection of type I atelocollagen supplements collagen levels in the disrupted articular cartilage. This randomized controlled trial evaluated the effects of the intra-articular injection of atelocollagen for the management of knee pain. DESIGN: Two hundred patients with osteoarthritis, chondromalacia, or other cartilage defects were randomly assigned to receive a 3-mL intra-articular injection of atelocollagen (BioCollagen group) or saline (Placebo group). Clinical improvement was evaluated over a 24-week period using the 100-mm visual analogue scale (VAS), the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), and the 36-item Short-Form Health Survey (SF-36). RESULTS: VAS scores were significantly better in the BioCollagen group as compared with the Placebo group at 24 weeks. More patients in the BioCollagen group reported exceeding 20% and 40% VAS improvements. The WOMAC and SF-36 scores were also significantly improved from baseline after the intra-articular injection of atelocollagen; although, the differences between the BioCollagen and Placebo groups were not significant. There were no unexpected or severe adverse events reported for either group. CONCLUSIONS: The results show that an intra-articular injection of atelocollagen effectively alleviates knee pain, as intended. Therefore, the intra-articular injection of atelocollagen can be considered an alternative solution to controlling knee pain due to osteoarthritis and diverse cartilage defects.
Authors: P Volpi; C Bait; A Quaglia; A Redaelli; E Prospero; M Cervellin; D Stanco; L de Girolamo Journal: Knee Surg Sports Traumatol Arthrosc Date: 2014-01-11 Impact factor: 4.342
Authors: Adrián Borja-Flores; Salvador I Macías-Hernández; Gabriela Hernández-Molina; Andric Perez-Ortiz; Eloy Reyes-Martínez; José Belzazar-Castillo de la Torre; Laura Ávila-Jiménez; María Cristina Vázquez-Bello; Marco Antonio León-Mazón; Janette Furuzawa-Carballeda; Gonzalo Torres-Villalobos; Fernanda Romero-Hernández; Cidronio Albavera-Hernández; Jesús Pérez-Correa; Hilda A Castro-Rocha Journal: Adv Orthop Date: 2020-07-22
Authors: Robert L Parisien; Michael Constant; Bryan M Saltzman; Charles A Popkin; Christopher S Ahmad; Xinning Li; David P Trofa Journal: Cartilage Date: 2021-05-10 Impact factor: 3.117