Impact of in situ acid generation and iodine sequestration on the chlorite-iodide clock reaction.

Acid generators, such as cyclic esters, have recently emerged as powerful modulators of clock reactions. Here, we show that a transient pH burst emerges when δ-gluconolactone is coupled to the chlorite-iodide reaction. The timing and strength of the bursts depend on the concentration of the cyclic ester and can be further modulated by sequestration of iodine by tetrabutylammonium cations or α-cyclodextrin. These findings could be useful for the design of new, transient pH- and complexation-driven self-assembly systems, as well as for analytical purposes.