| Literature DB >> 3137021 |
M W Jann1, G S Fidone, M K Israel, P Bonadero.
Abstract
Valproate (VPA) serum concentrations (Cp) were followed in six epileptic mentally retarded patients when carbamazepine (CBZ) was discontinued. VPA Cp significantly increased when CBZ was discontinued. A new plateau of VPA Cp was achieved 4 weeks post-CBZ discontinuation. This time factor is analogous to the autoinduction property of CBZ. Careful VPA Cp monitoring is recommended when CBZ or other enzyme inducing agents are discontinued.Entities:
Mesh：
Substances：
Year: 1988 PMID： 3137021 DOI： 10.1111/j.1528-1157.1988.tb03764.x
Source DB: PubMed Journal: Epilepsia ISSN： 0013-9580 Impact factor: 5.864