| Literature DB >> 31369255 |
Bruno Dias Nani1, Janaína de Cássia Orlandi Sardi1, Josy Goldoni Lazarini1, Diego Romário Silva1, Adna Prado Massariolli2, Thiago Mattar Cunha3, Severino Matias de Alencar2, Marcelo Franchin1, Pedro Luiz Rosalen1.
Abstract
Brazilian organic propolis (BOP) is an unexplored Brazilian propolis that is produced organically and certified according to international legislation. Our results showed that BOP has strong anti-inflammatory effects and acts by reducing nuclear factor κB activation, tumor necrosis factor α release, and neutrophil migration. In addition, BOP6 exhibited antifungal activity on planktonic and biofilm cultures of Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, and Candida parapsisolis and reduced in vitro yeast cell adhesion to human keratinocytes at sub-inhibitory concentrations. BOP demonstrated significantly low toxicity in Galleria melonella larvae at antifungal doses. Lastly, a chemical analysis revealed the presence of caffeoyltartaric acid, 3,4-dicaffeoylquinic acid, quercetin, and gibberellins A7, A9, and A20, which may be responsible for the biological properties observed. Thus, our data indicate that BOP is a promising source of anti-inflammatory and antifungal molecules that may be used as a functional food.Entities:
Keywords: 3,4-diCQA; 3,4-dicaffeoylquinic acid; antifungal; caffeoyltartaric acid; gibberellin; inflammation; propolis; quercetin
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Year: 2019 PMID： 31369255 DOI： 10.1021/acs.jafc.8b07304
Source DB: PubMed Journal: J Agric Food Chem ISSN： 0021-8561 Impact factor: 5.279