| Literature DB >> 31368354 |
Zhao-Kun Yin1, Zi-Ming Feng1, Jian-Shuang Jiang1, Xu Zhang1, Pei-Cheng Zhang1, Ya-Nan Yang1.
Abstract
Two new naturally occurring products named salviamine G (1) and 4-methyl-9-(ethoxycarbonyl)-8-naphthoic acid (2) were isolated from the rhizomes of Salvia miltiorrhiza. Their structures were elucidated using spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1 and 2 were screened for their inhibitory activity against HSV-1 and influenza A (H3N2) using acyclovir (ACV, IC50 = 0.67 μM) and oseltamivir (IC50 = 2.01 μM) as a positive control. Compound 1 exhibited moderate inhibitory activity against HSV-1 and influenza A (H3N2) with IC50 values of 11.11 and 8.62 μM, respectively.Entities:
Keywords: Labiatae; Salvia miltiorrhiza; antiviral activity; isolation and purification; structure elucidation; tanshinone diterpene derivatives
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Year: 2019 PMID： 31368354 DOI： 10.1080/10286020.2019.1645132
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569