| Literature DB >> 31368100 |
Jie Ding1, Zheng Yang2, Heng Ma3, Hao Zhang4.
Abstract
Myocardial ischemia-reperfusion (IR) injury during acute myocardial infarction or open-heart surgery would promote oxidative stress, leading to the accumulation of reactive aldehydes that cause cardiac damage. It has been well demonstrated that aldehyde dehydrogenase (ALDH)-2 is an important cardioprotective enzyme for its central role in the detoxification of reactive aldehydes. ALDH2 activation by small molecule activators is a promising approach for cardioprotection for myocardial IR injury.Entities:
Mesh：
Substances：
Year: 2019 PMID： 31368100 DOI： 10.1007/978-981-13-6260-6_6
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622