Literature DB >> 31367818

Study of dCTCF Insulator Activity in Drosophilamelanogaster Model Systems.

N E Postika1, T A Ivlieva2, P G Georgiev2, O V Kyrchanova2.   

Abstract

Using transgenic Drosophila model systems, we showed that four binding sites for the architectural protein dCTCF per se cannot form an effective insulator that blocks enhancers and protects against the Polycomb-dependent repression. These results suggest that, in the known Drosophila insulators, the dCTCF protein functions in cooperation with other architectural proteins.

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Year:  2019        PMID: 31367818     DOI: 10.1134/S1607672919030074

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN: 1607-6729            Impact factor:   0.788


  1 in total

1.  Fragments of the Fab-3 and Fab-4 Boundaries of the Drosophila melanogaster Bithorax Complex That Include CTCF Sites Are not Effective Insulators.

Authors:  O V Kyrchanova; N Y Postika; V V Sokolov; P G Georgiev
Journal:  Dokl Biochem Biophys       Date:  2022-03-11       Impact factor: 0.788

  1 in total

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