Literature DB >> 31366838

Synthesis and Anticancer Activity of New ((Furan-2-yl)-1,3,4-thiadiazolyl)-1,3,4-oxadiazole Acyclic Sugar Derivatives.

Asmaa F Kassem1, Ibrahim F Nassar2, Mohammed T Abdel-Aal3, Hanem M Awad4, Wael A El-Sayed5,6.   

Abstract

New sugar hydrazones incorporating furan and/or 1,3,4-thiadiazole ring systems were synthesized by reaction of the corresponding hydrazide with different aldose sugars. Heterocyclization of the formed hydrazones afforded the derived acyclic nucleoside analogues possessing the 1,3,4-oxadiazoline as modified nucleobase via acetylation followed by the heterocyclization process. The anticancer activity of the synthesized compounds was studied against human liver carcinoma cell (HepG-2) and at human normal retina pigmented epithelium cells (RPE-1). High activities were revealed by compounds 3, 12 and 14 with IC50 values near to that of the reference drug doxorubicin.

Entities:  

Keywords:  1,3,4-oxadiazole; acyclic nucleoside; anticancer; hydrazone; sugar; thiadiazole

Mesh：

Substances：

Year:  2019        PMID： 31366838     DOI： 10.1248/cpb.c19-00280

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  6 in total

1.  Design, Synthesis, Anticancer Evaluation, Enzymatic Assays, and a Molecular Modeling Study of Novel Pyrazole-Indole Hybrids.

Authors:  Ashraf S Hassan; Gaber O Moustafa; Hanem M Awad; Eman S Nossier; Mohamed F Mady
Journal:  ACS Omega       Date:  2021-04-29

2.  Design and Synthesis of Some New Furan-Based Derivatives and Evaluation of In Vitro Cytotoxic Activity.

Authors:  Syed Nasir Abbas Bukhari; Hasan Ejaz; Mervat A Elsherif; Kashaf Junaid; Islam Zaki; Reham E Masoud
Journal:  Molecules       Date:  2022-04-18       Impact factor: 4.927

3.  Antiproliferative Activity of Some Newly Synthesized Substituted Nicotinamides Candidates Using Pyridine-2(1H) thione Derivatives as Synthon.

Authors:  Dina H Elnaggar; Ashraf M Mohamed; Naglaa A Abdel Hafez; Mohamed E Azab; Manar E A Elasasy; Hanem M Awad; Thoraya A Farghaly; Abd El-Galil E Amr
Journal:  ACS Omega       Date:  2022-03-16

4.  Synthesis of novel naphthalene-heterocycle hybrids with potent antitumor, anti-inflammatory and antituberculosis activities.

Authors:  Mohamed Ahmed Abozeid; Aya Atef El-Sawi; Mohamed Abdelmoteleb; Hanem Awad; Marwa Mostafa Abdel-Aziz; Abdel-Rahman Hassan Abdel-Rahman; El-Sayed Ibrahim El-Desoky
Journal:  RSC Adv       Date:  2020-11-26       Impact factor: 4.036

5.  Synthesis and Cytotoxic Activity of New Thiazolopyrimidine Sugar Hydrazones and Their Derived Acyclic Nucleoside Analogues.

Authors:  Ebtesam A Basiony; Allam A Hassan; Zahra M Al-Amshany; Ahmed A Abd-Rabou; Adel A-H Abdel-Rahman; Nasser A Hassan; Wael A El-Sayed
Journal:  Molecules       Date:  2020-01-18       Impact factor: 4.411

6.  Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity.

Authors:  Adel A-H Abdel-Rahman; Amira K F Shaban; Ibrahim F Nassar; Dina S El-Kady; Nasser S M Ismail; Samy F Mahmoud; Hanem M Awad; Wael A El-Sayed
Journal:  Molecules       Date:  2021-06-26       Impact factor: 4.411
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.