Literature DB >> 31366440

Impact of mutations in hVISA isolates on decreased susceptibility to vancomycin, through population analyses profile - area under curve (PAP-AUC).

A C O Silveira1, J Caierão2, C I Silva3, E K Anzai4, J A McCulloch5, P A d'Azevedo6, T C M Sincero3.   

Abstract

We analyzed sequences of graSR, vraSR, walKR and rpoB genes in hVISA from Brazil. Five isolates showed mutations in at least one gene. rpoB H481N and graS T224I were the most frequent mutations, followed by graR D148Q and walK A468T. Our study reinforces the heterogeneity of genetic patterns among hVISA.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Two-component regulatory systems; VISA; hVISA; rpoB

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Year:  2019        PMID： 31366440     DOI： 10.1016/j.diagmicrobio.2019.06.006

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  2 in total

1.  Vancomycin MIC and agr dysfunction in invasive MRSA infections in southern Brazil.

Authors:  Adriana Medianeira Rossato; Muriel Primon-Barros; Cícero Armídio Gomes Dias; Pedro Alves d'Azevedo
Journal:  Braz J Microbiol       Date:  2020-10-19       Impact factor: 2.476

2.  Investigating the effect of an identified mutation within a critical site of PAS domain of WalK protein in a vancomycin-intermediate resistant Staphylococcus aureus by computational approaches.

Authors:  Neda Baseri; Shahin Najar-Peerayeh; Bita Bakhshi
Journal:  BMC Microbiol       Date:  2021-09-02       Impact factor: 3.605
  2 in total

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