Alen Zabotti1, Sara Zandonella Callegher1, Saviana Gandolfo1, Francesca Valent2, Ivan Giovannini1, Elena Cavallaro1, Michele Lorenzon3, Salvatore De Vita4. 1. Rheumatology Clinic, Department of Medical Area, Azienda Sanitaria Universitaria Integrata di Udine, Italy. 2. Institute of Hygiene and Clinical Epidemiology, Azienda Sanitaria Universitaria Integrata di Udine, Italy. 3. Institute of Radiology, Department of Medical Area, Azienda Sanitaria Universitaria Integrata di Udine, Italy. 4. Rheumatology Clinic, Department of Medical Area, Azienda Sanitaria Universitaria Integrata di Udine, Italy. salvatore.devita@asuiud.sanita.fvg.it.
Abstract
OBJECTIVES: In primary Sjögren's syndrome (pSS) dryness of eye and mouth is the cardinal referred symptom. Assessing the rate of activity and damage in the salivary glands of pSS patients is essential to improve disease management. Up to now, a differentiation of activity and damage ultrasonographic (US) lesions is an open issue. The aim of this preliminary study was to identify US lesions which better correlate with loss of function of salivary glands in pSS. METHODS: Salivary glands ultrasonography of consecutive patients with established pSS, fulfilling AECG and ACR/EULAR criteria was performed. The association between sialometry and Visual Analogue Scale (VAS) oral dryness and SGUS lesions was assessed trough univariate and multivariate analysis. RESULTS: In 75 established pSS patients, mean disease duration 12.4±7.2 years, the hyperechoic bands of parotid gland (PG) and submandibular gland (SMG) were significantly associated with sialometry (p<0.001) and VAS oral dryness (PG p=0.002, SMG p<0.001). The global glandular involvement (scored according to De Vita et al., 1992) was associated with sialometry (PG p=0.025, SMG p<0.001) and with VAS oral sicca (PG p=0.015, SMG p<0.001). The multivariate analysis selected the hyperechoic bands of PG and SMG as the variables independently associated with sialometry and the hyperechoic bands and the homogeneity in the SMG as associated with VAS oral dryness. CONCLUSIONS: These results indicate that salivary impairment in pSS, as objectively evaluated by sialometry, could be mainly associated with damage (i.e., hyperechoic bands) in established pSS. Additional follow-up studies and improved scoring tools are needed.
OBJECTIVES: In primary Sjögren's syndrome (pSS) dryness of eye and mouth is the cardinal referred symptom. Assessing the rate of activity and damage in the salivary glands of pSS patients is essential to improve disease management. Up to now, a differentiation of activity and damage ultrasonographic (US) lesions is an open issue. The aim of this preliminary study was to identify US lesions which better correlate with loss of function of salivary glands in pSS. METHODS: Salivary glands ultrasonography of consecutive patients with established pSS, fulfilling AECG and ACR/EULAR criteria was performed. The association between sialometry and Visual Analogue Scale (VAS) oral dryness and SGUS lesions was assessed trough univariate and multivariate analysis. RESULTS: In 75 established pSS patients, mean disease duration 12.4±7.2 years, the hyperechoic bands of parotid gland (PG) and submandibular gland (SMG) were significantly associated with sialometry (p<0.001) and VAS oral dryness (PG p=0.002, SMG p<0.001). The global glandular involvement (scored according to De Vita et al., 1992) was associated with sialometry (PG p=0.025, SMG p<0.001) and with VAS oral sicca (PG p=0.015, SMG p<0.001). The multivariate analysis selected the hyperechoic bands of PG and SMG as the variables independently associated with sialometry and the hyperechoic bands and the homogeneity in the SMG as associated with VAS oral dryness. CONCLUSIONS: These results indicate that salivary impairment in pSS, as objectively evaluated by sialometry, could be mainly associated with damage (i.e., hyperechoic bands) in established pSS. Additional follow-up studies and improved scoring tools are needed.
Authors: Sara Zandonella Callegher; Alen Zabotti; Ivan Giovannini; Elena Treppo; Luca Quartuccio; Salvatore De Vita Journal: Front Med (Lausanne) Date: 2020-12-09
Authors: Alen Zabotti; Sara Zandonella Callegher; Annarita Tullio; Arso Vukicevic; Alojzija Hocevar; Vera Milic; Giacomo Cafaro; Marina Carotti; Konstantina Delli; Orazio De Lucia; Diana Ernst; Francesco Ferro; Angelica Gattamelata; Giuseppe Germanò; Ivan Giovannini; Daniel Hammenfors; Malin V Jonsson; Sandrine Jousse-Joulin; Pierluigi Macchioni; Simone Parisi; Carlo Perricone; Martin Helmut Stradner; Nenad Filipovic; Athanasios G Tzioufas; Francesca Valent; Salvatore De Vita Journal: Front Med (Lausanne) Date: 2020-11-23
Authors: Michele Lorenzon; Erica Spina; Francesco Tulipano Di Franco; Ivan Giovannini; Salvatore De Vita; Alen Zabotti Journal: Open Access Rheumatol Date: 2022-09-01