| Literature DB >> 31364880 |
Tarik A Mohamed1, Abeer A Abd El Aty2,3, Abdelaaty A Shahat1,4, Nahla S Abdel-Azim1, Khaled A Shams1, Abdelsamed A Elshamy5, Mehawed M Ahmed6, Sabry H H Youns6, Taher M El-Wassimy6, Sayed A El-Toumy7, Mohamed-Elamir F Hegazy1,8.
Abstract
Artemisia herba-alba is widely used in traditional medicines for the treatment of several diseases. From the aerial parts organic extract of A. herba-alba, two new compounds, 1,3,8-trihydroxyeudesm-4-en-7α,11βH-12,6α-olide (1) and 5-β-D-glucopyranosyloxy-7-methoxy-6H-benzopyran-2-one (2), respectively, together with five known metabolites: 3α,8β-dihydroxygermacr-4(15),9(10)-dien-7β,11αH,12,6α-olide (3), 1β,8α-dihydroxy-11α,13-dihydrobalchanin (4), 11-epiartapshin (5), tomenin (6) and benzoic acid, p-(β-D-glucopyranosyloxy)-methyl ester (7), were isolated and identified. The chemical structures were proven depending upon spectroscopic analysis, including 1 D/2D NMR as and ESI-MS. Compound 1 inhibited Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. Compounds 2 and 3 exhibited antibacterial activity against both gram-positive and gram-negative bacteria.Entities:
Keywords: Artemisia herba-alba; antimicrobial activity; coumarin glucoside; phenolics; sesquiterpenes
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Year: 2019 PMID： 31364880 DOI： 10.1080/14786419.2019.1647430
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861