Literature DB >> 31364690

Myocardial protection: a forgotten modality.

Bradley S Allen1.   

Abstract

The goals of a cardiac surgical procedure are both technical excellence and complete protection of cardiac function. Cardioplegia is used almost universally to protect the heart and provide a quiet bloodless field for surgical accuracy. Yet, despite the importance of myocardial protection in cardiac surgery, manuscripts or dedicated sessions at major meetings on this subject have become relatively rare, as though contemporary techniques now make them unnecessary. Nevertheless, septal dysfunction and haemodynamic support (inotropes, intra-aortic balloon pump, assist devices) are common in postoperative patients, indicating that myocardial damage following cardiac surgery is still prevalent with current cardioplegic techniques and solutions. This article first describes why cardiac enzymes and septal function are the ideal markers for determining the adequacy of myocardial protection. It also describes the underappreciated consequences of postoperative cardiac enzyme release or septal dysfunction (which currently occurs in 40-80% of patients) from inadequate protection, and how they directly correlate with early and especially late mortality. Finally, it reviews the various myocardial protection techniques available to provide a detailed understanding of the cardioplegic methods that can be utilized to protect the heart. This will allow surgeons to critically assess their current method of protection and, if needed, make necessary changes to provide their patients with optimal protection.
© The Author(s) 2019. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Entities:  

Keywords:  Cardioplegia; Diastolic dysfunction; Myocardial damage; Myocardial protection; Septal dysfunction

Year:  2020        PMID: 31364690     DOI: 10.1093/ejcts/ezz215

Source DB:  PubMed          Journal:  Eur J Cardiothorac Surg        ISSN: 1010-7940            Impact factor:   4.191


  1 in total

1.  Clinically inapparent right heart dysfunction is associated with reduced myofilament force development in coronary artery disease.

Authors:  C Bening; V L Sales; K Alhussini; D Radakovic; R Cris Benitez; N Madrahimov; D Keller; R Leyh
Journal:  BMC Cardiovasc Disord       Date:  2021-03-05       Impact factor: 2.298

  1 in total

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