Ana Galvão1, Gunes Karakus2, Annalisa Racca3, Samuel Santos-Ribeiro4, Neelke De Munck3, Panagiotis Drakopoulos3, Michel De Vos3, Greta Verheyen3, Herman Tournaye3, Christophe Blockeel5. 1. Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Department of Obstetrics and Gynaecology, Centro Materno Infantil do Norte, Centro Hospitalar do Porto, Largo da Maternidade de Júlio Dinis 30, 4050-651 Porto, Portugal. 2. Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Department of Obstetrics and Gynaecology, Santarem Hospital, R. Zeferino Silva, Santarém, Portugal. 3. Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium. 4. Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; IVI-RMA Lisboa, Avenida Infante Dom Henrique 333 H 1-9, Lisbon 1800-282, Portugal. 5. Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; University of Zagreb-School of Medicine, Department of Obstetrics and Gynaecology Zagreb, Croatia. Electronic address: christophe.blockeel@uzbrussel.be.
Abstract
RESEARCH QUESTION: Does the levonorgestrel-releasing intrauterine device (LNG-IUD) influence cumulative live birth rate (CLBR) in oocyte donor cycles? DESIGN: Retrospective cohort study based on prospectively collected data from 1 May 2009 to 31 December 2017, without attrition, consisting of 491 consecutive cycles of vitrified oocyte donation, none lost to follow-up (unique donor-recipient pairs). All donors underwent ovarian stimulation using gonadotrophin releasing hormone (GnRH) antagonist co-treatment and GnRH agonist trigger. CLBR was chosen as primary outcome measure. RESULTS: In total, 103 (21.0%) cycles were carried out in donors carrying a LNG-IUD. In 388 (79.0%) cycles, no LNG-IUD was present. After confounder-adjustment, the use of an LNG-IUD did not have a statistically significant influence on CLBR. CONCLUSIONS: The LNG-IUD does not negatively affect CLBR.
RESEARCH QUESTION: Does the levonorgestrel-releasing intrauterine device (LNG-IUD) influence cumulative live birth rate (CLBR) in oocyte donor cycles? DESIGN: Retrospective cohort study based on prospectively collected data from 1 May 2009 to 31 December 2017, without attrition, consisting of 491 consecutive cycles of vitrified oocyte donation, none lost to follow-up (unique donor-recipient pairs). All donors underwent ovarian stimulation using gonadotrophin releasing hormone (GnRH) antagonist co-treatment and GnRH agonist trigger. CLBR was chosen as primary outcome measure. RESULTS: In total, 103 (21.0%) cycles were carried out in donors carrying a LNG-IUD. In 388 (79.0%) cycles, no LNG-IUD was present. After confounder-adjustment, the use of an LNG-IUD did not have a statistically significant influence on CLBR. CONCLUSIONS: The LNG-IUD does not negatively affect CLBR.
Authors: Marjan Van Reckem; Christophe Blockeel; Maryse Bonduelle; Andrea Buysse; Mathieu Roelants; Greta Verheyen; Herman Tournaye; Frederik Hes; Florence Belva Journal: Hum Reprod Open Date: 2021-02-19