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Literature DB >> 31362288

Pathophysiology of Diabetic Retinopathy: Contribution and Limitations of Laboratory Research.

Timothy S Kern^1,2, David A Antonetti³, Lois E H Smith⁴.

Abstract

Preclinical models of diabetic retinopathy are indispensable in the drug discovery and development of new therapies. They are, however, imperfect facsimiles of diabetic retinopathy in humans. This chapter discusses the advantages, limitations, and physiological and pathological relevance of preclinical models of diabetic retinopathy. The judicious interpretation and extrapolation of data derived from these models to humans and a correspondingly greater emphasis placed on translational medical research in early-stage clinical trials are essential to more successfully inhibit the development and progression of diabetic retinopathy in the future.

Entities: Chemical Disease Gene Species

Keywords: Diabetic retinopathy; Laboratory research; Preclinical models

Mesh：

Year: 2019 PMID： 31362288 PMCID： PMC6872907 DOI： 10.1159/000500026

Source DB: PubMed Journal: Ophthalmic Res ISSN： 0030-3747 Impact factor: 2.892

84 in total

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Authors: Jonathan E Noonan; Alicia J Jenkins; Jian-Xing Ma; Anthony C Keech; Jie Jin Wang; Ecosse L Lamoureux
Journal: Diabetes Date: 2013-12 Impact factor: 9.461

14 in total

1. Disruption of retinal inflammation and the development of diabetic retinopathy in mice by a CD40-derived peptide or mutation of CD40 in Müller cells.

Authors: Jose-Andres C Portillo; Jin-Sang Yu; Sarah Vos; Reena Bapputty; Yalitza Lopez Corcino; Alyssa Hubal; Jad Daw; Sahil Arora; Wenyu Sun; Zheng-Rong Lu; Carlos S Subauste
Journal: Diabetologia Date: 2022-08-03 Impact factor: 10.460

2. Three-dimensional spheroids of choroid-retinal vascular endothelial cells as an in-vitro model for diabetic retinopathy: Proof-of-concept investigation.

Authors: Manish Gore; Ankit Tiwari; Devashree Jahagirdar; Angayarkanni Narayanasamy; Ratnesh Jain; Prajakta Dandekar
Journal: Curr Res Pharmacol Drug Discov Date: 2022-05-21

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Authors: Ka-Ho Wong; Katherine Hu; Cecilia Peterson; Nazanin Sheibani; Georgios Tsivgoulis; Jennifer J Majersik; Adam H de Havenon
Journal: Stroke Date: 2020-10-06 Impact factor: 7.914

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Authors: Islam N Mohamed; Nader Sheibani; Azza B El-Remessy
Journal: Int J Mol Sci Date: 2020-06-01 Impact factor: 5.923

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Authors: Ricardo Raúl Robles-Rivera; José Alberto Castellanos-González; Cecilia Olvera-Montaño; Raúl Alonso Flores-Martin; Ana Karen López-Contreras; Diana Esperanza Arevalo-Simental; Ernesto Germán Cardona-Muñoz; Luis Miguel Roman-Pintos; Adolfo Daniel Rodríguez-Carrizalez
Journal: Oxid Med Cell Longev Date: 2020-03-11 Impact factor: 6.543