M Ruggeri1, E Pagan2, V Bagnardi2, N Bianco3, E Gallerani4, K Buser5, M Giordano6, L Gianni7, M Rabaglio8, A Freschi9, E Cretella10, M Clerico11, A Farolfi12, E Simoncini13, M Ciccarese14, D Rauch15, M Ramello16, A Glaus17, R Berardi18, A Franzetti Pellanda19, K Ribi20, S Gelber21, A H Partridge22, A Goldhirsch23, O Pagani24. 1. Program for Young Patients, International Breast Cancer Study Group, Bern, Switzerland. Electronic address: monica.ruggeri@ibcsg.org. 2. Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano - Bicocca, Milan, Italy. 3. Division of Medical Senology, IEO, European Institute of Oncology IRCCS, Milan, Italy. 4. Breast Cancer Unit, Ospedale Multimedica, Castellanza, VA, Italy. 5. Division of Oncology (Oncocare), Klinik Engeried, Lindenhofgruppe, Bern, Switzerland. 6. Medical Oncology Unit, Ospedale Sant'Anna, Como, Italy. 7. Department of Medical Oncology, Ospedale Infermi, Rimini, AUSL della Romagna, Italy. 8. University Clinic for Medical Oncology, Inselspital, Bern, Switzerland. 9. Department of Medical Oncology, CRO, Aviano, Italy. 10. Department of Medical Oncology, Azienda Sanitaria Dell'Alto Adige, Bolzano, Italy. 11. Department of Medical Oncology, Ospedale Degli Infermi, Biella, Italy. 12. Department of Medical Oncology, Istituto Scientifico Romagnolo per Lo Studio e La Cura Dei Tumori IRCCS, Meldola, Italy. 13. Breast Unit, ASST Spedali Civili di Brescia, Brescia, Italy. 14. U.O. Oncologia Medica, Vito Fazzi Hospital, Lecce, Italy. 15. Medical Oncology, Spital STS, Thun, Switzerland. 16. Department of Medical Oncology, Azienda ULSS 9, Treviso, Italy. 17. Tumor- and Breast Center ZeTup, St. Gallen, Switzerland. 18. Department of Medical Oncology, Università Politecnica Delle Marche, A.O.U. Ospedali Riuniti di Ancona, Ancona, Italy. 19. Radiotherapy Service, Clinica Luganese Moncucco, Lugano, Switzerland. 20. Quality of Life Office, International Breast Cancer Study Group, Bern, Switzerland. 21. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 22. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 23. International Breast Cancer Study Group, Bern, Switzerland; MultiMedica, Milan, Italy. 24. Institute of Oncology and Breast Unit of Southern Switzerland, Bellinzona, Switzerland; Geneva University Hospitals, Geneva, Switzerland.
Abstract
OBJECTIVES: Most research addressing needs and concerns of young patients with breast cancer (≤40 years) is retrospective. The HOHO European protocol is a prospective multicenter cohort study of young women with newly diagnosed breast cancer, about fertility, psychosocial and quality of life concerns. Here we report the baseline data and focus on predictors of fertility concerns. MATERIALS AND METHODS: Patient surveys and medical record review were used. The baseline survey included sociodemographic, medical and treatment data as well as questions on fertility concerns and preservation strategies. Subscales from the CAncer Rehabilitation Evaluation System-Short Form (CARES-SF) were administered to measure specific quality of life aspects. Uni- and multivariable modeling were used to investigate predictors of greater fertility concern. RESULTS: Among 297 eligible respondents, 67% discussed fertility issues before starting therapy, 64% were concerned about becoming infertile after treatment, and 15% decided not to follow prescribed therapies. Fifty-four percent of women wished future children before diagnosis; of these, 71% still desired biologic children afterwards. In multivariable analysis, not having children was the only patient characteristic significantly associated with fertility concerns at diagnosis. Twenty-seven percent used fertility preservation strategies. Women who received chemotherapy reported greater physical (p = 0.021) and sexual difficulties (p = 0.039) than women who did not. Women who were married or had a partner reported less psychosocial problems than single women (p = 0.039). CONCLUSIONS: Young women with newly diagnosed breast cancer have several concerns, including, but not limited to, fertility. The HOHO European study provides valuable information to develop targeted interventions.
OBJECTIVES: Most research addressing needs and concerns of young patients with breast cancer (≤40 years) is retrospective. The HOHO European protocol is a prospective multicenter cohort study of young women with newly diagnosed breast cancer, about fertility, psychosocial and quality of life concerns. Here we report the baseline data and focus on predictors of fertility concerns. MATERIALS AND METHODS:Patient surveys and medical record review were used. The baseline survey included sociodemographic, medical and treatment data as well as questions on fertility concerns and preservation strategies. Subscales from the CAncer Rehabilitation Evaluation System-Short Form (CARES-SF) were administered to measure specific quality of life aspects. Uni- and multivariable modeling were used to investigate predictors of greater fertility concern. RESULTS: Among 297 eligible respondents, 67% discussed fertility issues before starting therapy, 64% were concerned about becoming infertile after treatment, and 15% decided not to follow prescribed therapies. Fifty-four percent of women wished future children before diagnosis; of these, 71% still desired biologic children afterwards. In multivariable analysis, not having children was the only patient characteristic significantly associated with fertility concerns at diagnosis. Twenty-seven percent used fertility preservation strategies. Women who received chemotherapy reported greater physical (p = 0.021) and sexual difficulties (p = 0.039) than women who did not. Women who were married or had a partner reported less psychosocial problems than single women (p = 0.039). CONCLUSIONS: Young women with newly diagnosed breast cancer have several concerns, including, but not limited to, fertility. The HOHO European study provides valuable information to develop targeted interventions.
Authors: Tal Sella; Philip D Poorvu; Kathryn J Ruddy; Shari I Gelber; Rulla M Tamimi; Jeffrey M Peppercorn; Lidia Schapira; Virginia F Borges; Steven E Come; Ann H Partridge; Shoshana M Rosenberg Journal: Cancer Date: 2021-04-22 Impact factor: 6.921
Authors: Valentino Martelli; Maria Maddalena Latocca; Tommaso Ruelle; Marta Perachino; Luca Arecco; Kristi Beshiri; Maria Grazia Razeti; Marco Tagliamento; Maurizio Cosso; Piero Fregatti; Matteo Lambertini Journal: Breast Cancer (Dove Med Press) Date: 2021-05-24
Authors: Maren Goeckenjan; A Freis; K Glaß; J Schaar; I Trinkaus; S Torka; P Wimberger; A Germeyer Journal: Arch Gynecol Obstet Date: 2020-05-06 Impact factor: 2.344