Skeletal-related adverse events during bone metastasis of breast cancer: current status.

Skeletal-related events are severe problems in patients with breast cancer. Bone metastasis and endocrine therapy are closely related to skeletal morbidity and mortality. Skeletal-related events during breast cancer tumorigenesis lead to the exacerbated poor life quality of patients. This review summarizes recent advances in our understanding of the characteristics of skeletal-related events during bone metastasis of breast cancer, especially on the major cause of skeletal-related events, early diagnosis and threshold of anti-absorption treatment. Finally, we highlight novel approaches for the diagnosis and treatment of skeletal-related events during bone metastasis of breast cancer.