Literature DB >> 3136111

Transplantable osteosarcomas with high lung metastatic potential in Fischer 344 rats.

Y Mii1, M Tsutsumi, K Shiraiwa, Y Miyauchi, K Hohnoki, H Maruyama, H Ogushi, K Masuhara, Y Konishi.   

Abstract

Both spontaneous (SOS) and 4-hydroxyaminoquinoline 1-oxide (4-HAQO)-induced osteosarcomas (COS) could be serially transplanted in the subcutaneous back space of syngeneic F344 rats, the success rate becoming 100% within 5 passage generations. Transplanted tumors demonstrated rapid growth and displayed high potential for metastasis to the lung in later generations. Thus, a 100% lung metastasis rate was observed for SOS after the 20th and for COS after the 14th generation. The histological features of the primary SOS and COS were retained during serial transfer. These model systems should be useful for investigation of the biology of this very important tumor type.

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Year:  1988        PMID： 3136111      PMCID： PMC5917555          DOI： 10.1111/j.1349-7006.1988.tb00027.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  5 in total

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Authors:  I J Fidler; M L Kripke
Journal:  Science       Date:  1977-08-26       Impact factor: 47.728

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Authors:  M M Albala; A R Esparza
Journal:  Cancer Res       Date:  1969-08       Impact factor: 12.701

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Authors:  D C Dahlin; M B Coventry
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5.  A spontaneous transplantable osteogenic sarcoma in AKR/Ms mice.

Authors:  K Nakakuki; K Shimokawa; H Yamauchi; A Ojima
Journal:  Gan       Date:  1976-08
  5 in total
  5 in total

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Review 2.  Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth).

Authors:  Stacey Fossey; John Vahle; Philip Long; Scott Schelling; Heinrich Ernst; Rogely Waite Boyce; Jacquelin Jolette; Brad Bolon; Alison Bendele; Matthias Rinke; Laura Healy; Wanda High; Daniel Robert Roth; Michael Boyle; Joel Leininger
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3.  An experimental transplantable osteosarcoma with spontaneous pulmonary metastasis in hamsters.

Authors:  M Sekiguchi; T Satomura; M Saëgusa; H Takeuchi; K Asanuma; T Shimoda
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4.  Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4-dihydroc arbostyril, a novel matrix metalloproteinase inhibitor.

Authors:  A Kido; M Tsutsumi; K Iki; M Motoyama; M Takahama; T Tsujiuchi; T Morishita; K Tatsumi; S Tamai; Y Konishi
Journal:  Jpn J Cancer Res       Date:  1999-03

5.  Telomerase activity correlates with growth of transplantable osteosarcomas in rats treated with cis-diammine dichloroplatinum or the angiogenesis inhibitor AGM-1470.

Authors:  A Kido; T Tsujiuchi; T Morishita; M Tsutsumi; M Takahama; Y Miyauchi; Y Mii; S Tamai; Y Konishi
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  5 in total

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