| Literature DB >> 31359606 |
Hye-Jin Kim1,2, Sung Won Hur1, Jun Bum Park1, Jieun Seo1, Jae Jin Shin1,3, Seon-Young Kim1, Myoung-Hwan Kim1, Do Hyun Han4, Jong-Wan Park2, Joo Min Park3, Sang Jeong Kim1,2, Yang-Sook Chun1,2.
Abstract
Long-term memory formation is attributed to experience-dependent gene expression. Dynamic changes in histone methylation are essential for the epigenetic regulation of memory consolidation-related genes. Here, we demonstrate that the plant homeodomain finger protein 2 (PHF2) histone demethylase is upregulated in the mouse hippocampus during the experience phase and plays an essential role in memory formation. PHF2 promotes the expression of memory-related genes by epigenetically reinforcing the TrkB-CREB signaling pathway. In behavioral tests, memory formation is enhanced by transgenic overexpression of PHF2 in mice, but is impaired by silencing PHF2 in the hippocampus. Electrophysiological studies reveal that PHF2 elevates field excitatory postsynaptic potential (fEPSP) and NMDA receptor-mediated evoked excitatory postsynaptic current (EPSC) in CA1 pyramidal neurons, suggesting that PHF2 promotes long-term potentiation. This study provides insight into the epigenetic regulation of learning and memory formation, which advances our knowledge to improve memory in patients with degenerative brain diseases.Entities:
Keywords: CREB; PHF2; hippocampus; learning and memory; lysine methylation
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Year: 2019 PMID： 31359606 PMCID： PMC6726911 DOI： 10.15252/embr.201845907
Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807