Karla Romero Starke1, Marlen Kofahl2, Alice Freiberg2, Melanie Schubert2, Mascha Luisa Groß2, Stefanie Schmauder2, Janice Hegewald2, Daniel Kämpf2, Johanna Stranzinger3, Albert Nienhaus3,4, Andreas Seidler2. 1. Institute and Policlinic of Occupational and Social Medicine (IPAS), Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. karla.romero_starke@tu-dresden.de. 2. Institute and Policlinic of Occupational and Social Medicine (IPAS), Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. 3. Institution for Statutory Social Accident Insurance and Prevention in the Health Care and Welfare Services (BGW), Basic Principles of Prevention and Rehabilitation, Section Occupational Health, Hamburg, Germany. 4. Competence Centre for Epidemiology and Health Services Research for Healthcare Professionals (CVcare), University Medical Centre Hamburg-Eppendorf (UKE), Hamburg, Germany.
Abstract
PURPOSE: The primary aim of this review was to summarize the evidence on the relationship between being a daycare worker working with children and the possible increased risk of cytomegalovirus infection. METHODS: We searched the Medline and Embase databases using search strings defined according to the population, exposure, comparison, and outcomes (PECO) applicable to our research questions in order to find studies published since 2000. Two independent reviewers evaluated the search hits using predefined inclusion and exclusion criteria. A manual search was performed to identify additional relevant literature. We extracted the resulting studies and assessed them in eight domains of bias. The pooled CMV seroprevalence for daycare workers compared to the general population was calculated. RESULTS: After evaluating the 6879 records, six methodologically adequate studies were identified: five cross-sectional studies and one cohort study. The pooled seroprevalence of daycare workers was 59.3% (95% CI 47.6-70.9). The four studies investigating risk of infection indicated an increased seroprevalence for daycare workers compared to a reference population (prevalence ratio, PR = 1.54, 95% CI 1.33-1.77). No study evaluated CMV seroconversions for daycare workers. CONCLUSIONS: Our findings suggest a higher CMV seroprevalence for daycare workers compared to the general population. Notwithstanding the need for longitudinal and intervention studies, preventative efforts are needed. A pooled PR of 1.54 is compatible with a doubled seroconversion risk corresponding to a vocational probability of 50% if the substantial underestimation of the actual occupational seroconversion risk by prevalence-based estimators is considered.
PURPOSE: The primary aim of this review was to summarize the evidence on the relationship between being a daycare worker working with children and the possible increased risk of cytomegalovirus infection. METHODS: We searched the Medline and Embase databases using search strings defined according to the population, exposure, comparison, and outcomes (PECO) applicable to our research questions in order to find studies published since 2000. Two independent reviewers evaluated the search hits using predefined inclusion and exclusion criteria. A manual search was performed to identify additional relevant literature. We extracted the resulting studies and assessed them in eight domains of bias. The pooled CMV seroprevalence for daycare workers compared to the general population was calculated. RESULTS: After evaluating the 6879 records, six methodologically adequate studies were identified: five cross-sectional studies and one cohort study. The pooled seroprevalence of daycare workers was 59.3% (95% CI 47.6-70.9). The four studies investigating risk of infection indicated an increased seroprevalence for daycare workers compared to a reference population (prevalence ratio, PR = 1.54, 95% CI 1.33-1.77). No study evaluated CMV seroconversions for daycare workers. CONCLUSIONS: Our findings suggest a higher CMV seroprevalence for daycare workers compared to the general population. Notwithstanding the need for longitudinal and intervention studies, preventative efforts are needed. A pooled PR of 1.54 is compatible with a doubled seroconversion risk corresponding to a vocational probability of 50% if the substantial underestimation of the actual occupational seroconversion risk by prevalence-based estimators is considered.
Authors: Jennifer D Stowell; Daniela Forlin-Passoni; Erica Din; Kay Radford; Denise Brown; Audrey White; Sheri L Bate; Sheila C Dollard; Stephanie R Bialek; Michael J Cannon; D Scott Schmid Journal: J Infect Dis Date: 2011-11-23 Impact factor: 5.226
Authors: D F Stroup; J A Berlin; S C Morton; I Olkin; G D Williamson; D Rennie; D Moher; B J Becker; T A Sipe; S B Thacker Journal: JAMA Date: 2000-04-19 Impact factor: 56.272
Authors: Jutte J C de Vries; Erik W van Zwet; Friedo W Dekker; Aloys C M Kroes; Paul H Verkerk; Ann C T M Vossen Journal: Rev Med Virol Date: 2013-04-05 Impact factor: 6.989
Authors: S Stagno; R F Pass; M E Dworsky; R E Henderson; E G Moore; P D Walton; C A Alford Journal: N Engl J Med Date: 1982-04-22 Impact factor: 91.245
Authors: Gini G C van Rijckevorsel; Lian P M J Bovée; Marjolein Damen; Gerard J B Sonder; Maarten F Schim van der Loeff; Anneke van den Hoek Journal: BMC Public Health Date: 2012-06-22 Impact factor: 3.295
Authors: P Paul F M Kuijer; Jos H Verbeek; Andreas Seidler; Rolf Ellegast; Carel T J Hulshof; Monique H W Frings-Dresen; Henk F Van der Molen Journal: Neurology Date: 2018-08-17 Impact factor: 9.910
Authors: Raskit Lachmann; Anna Loenenbach; Tim Waterboer; Nicole Brenner; Michael Pawlita; Angelika Michel; Michael Thamm; Christina Poethko-Müller; Ole Wichmann; Miriam Wiese-Posselt Journal: PLoS One Date: 2018-07-25 Impact factor: 3.240
Authors: Safari Joseph Balegamire; Elisabeth McClymont; Agathe Croteau; Philippe Dodin; Soren Gantt; Amir Abbas Besharati; Christian Renaud; Benoît Mâsse; Isabelle Boucoiran Journal: Syst Rev Date: 2022-06-27
Authors: Witold Lewandowski; Carla Talarico; Karen Fowler; Jacek Mucha; Monika Neumann; Magdalena Kaczanowska; Maciej Grys; Elvira Schmidt; Andrew Natenshon; Philip O Buck; John Diaz-Decaro Journal: BMC Public Health Date: 2022-09-01 Impact factor: 4.135
Authors: Karla Romero Starke; Sophie Friedrich; Melanie Schubert; Daniel Kämpf; Maria Girbig; Anna Pretzsch; Albert Nienhaus; Andreas Seidler Journal: Int J Environ Res Public Health Date: 2021-05-13 Impact factor: 3.390
Authors: Karla Romero Starke; René Mauer; Ethel Karskens; Anna Pretzsch; David Reissig; Albert Nienhaus; Anna Lene Seidler; Andreas Seidler Journal: Int J Environ Res Public Health Date: 2021-06-21 Impact factor: 3.390
Authors: Ulrich Bolm-Audorff; Janice Hegewald; Anna Pretzsch; Alice Freiberg; Albert Nienhaus; Andreas Seidler Journal: Int J Environ Res Public Health Date: 2020-08-28 Impact factor: 3.390