Literature DB >> 3135804

Phosphatidylinositol-specific phospholipase D: a pathway for generation of a second messenger.

J Balsinde1, E Diez, F Mollinedo.   

Abstract

We have found a phospholipase D activity in the postnuclear fraction of human neutrophils which is stimulated by incubation of cells with the calcium ionophore A23187. The phospholipase D activity was assessed by both phosphatidate formation and free inositol release from phosphatidylinositol substrate. The phospholipase D activity shows an optimum pH of 7.5 and hydrolyzes specifically phosphatidylinositol. These results suggest that this phosphatidylinositol-specific phospholipase D can play a role in cell activating process.

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Year:  1988        PMID： 3135804     DOI： 10.1016/0006-291x(88)90168-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

Review 1.  The regulation and cellular functions of phosphatidylcholine hydrolysis.

Authors:  M M Billah; J C Anthes
Journal:  Biochem J       Date:  1990-07-15       Impact factor: 3.857

2.  Accumulation of phosphatidic acid mass and increased de novo synthesis of glycerolipids in platelet-activating-factor-activated human neutrophils.

Authors:  J Tou; J R Jeter; C P Dola; S Venkatesh
Journal:  Biochem J       Date:  1991-12-15       Impact factor: 3.857

Review 3.  Phospholipase D: molecular and cell biology of a novel gene family.

Authors:  M Liscovitch; M Czarny; G Fiucci; X Tang
Journal:  Biochem J       Date:  2000-02-01       Impact factor: 3.857

Review 4.  The role of neutrophils in vascular injury: a summary of signal transduction mechanisms in cell/cell interactions.

Authors:  G Weissmann
Journal:  Springer Semin Immunopathol       Date:  1989

5.  Phosphatidate-dependent protein phosphorylation.

Authors:  S B Bocckino; P B Wilson; J H Exton
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

6.  Guanosine 5'-[gamma-thio]triphosphate-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate in HL-60 granulocytes. Evidence that the guanine nucleotide acts by relieving phospholipase C from an inhibitory constraint.

Authors:  M Camps; C F Hou; K H Jakobs; P Gierschik
Journal:  Biochem J       Date:  1990-11-01       Impact factor: 3.857

7.  Phospholipase D-modified low density lipoprotein is taken up by macrophages at increased rate. A possible role for phosphatidic acid.

Authors:  M Aviram; I Maor
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

8.  Accumulation of inositol polyphosphate isomers in agonist-stimulated cerebral-cortex slices. Comparison with metabolic profiles in cell-free preparations.

Authors:  I H Batty; A J Letcher; S R Nahorski
Journal:  Biochem J       Date:  1989-02-15       Impact factor: 3.857

9.  Prostacyclin inhibits platelet aggregation induced by phorbol ester or Ca2+ ionophore at steps distal to activation of protein kinase C and Ca2+-dependent protein kinases.

Authors:  W Siess; E G Lapetina
Journal:  Biochem J       Date:  1989-02-15       Impact factor: 3.857

10.  v-Src activates a unique phospholipase D activity that can be distinguished from the phospholipase D activity activated by phorbol esters.

Authors:  J Song; D A Foster
Journal:  Biochem J       Date:  1993-09-15       Impact factor: 3.857
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