Literature DB >> 31357871

Oral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats.

Carmen D Tekwe1,2, Kang Yao1, Jian Lei1, Xilong Li1, Anand Gupta2, Yuanyuan Luan2, Cynthia J Meininger3, Fuller W Bazer1, Guoyao Wu1,3.   

Abstract

Entities:  

Keywords:  Metabolism; leucine; obesity; rats

Year:  2019        PMID： 31357871      PMCID： PMC6775570          DOI： 10.1177/1535370219865229

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


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  38 in total

1.  Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity.

Authors:  M Stumvoll; A Mitrakou; W Pimenta; T Jenssen; H Yki-Järvinen; T Van Haeften; W Renn; J Gerich
Journal:  Diabetes Care       Date:  2000-03       Impact factor: 19.112

Review 2.  Obesity-associated hypertension: new insights into mechanisms.

Authors:  Kamal Rahmouni; Marcelo L G Correia; William G Haynes; Allyn L Mark
Journal:  Hypertension       Date:  2004-12-06       Impact factor: 10.190

3.  Oral administration of interferon tau enhances oxidation of energy substrates and reduces adiposity in Zucker diabetic fatty rats.

Authors:  Carmen D Tekwe; Jian Lei; Kang Yao; Reza Rezaei; Xilong Li; Sudath Dahanayaka; Raymond J Carroll; Cynthia J Meininger; Fuller W Bazer; Guoyao Wu
Journal:  Biofactors       Date:  2013-06-27       Impact factor: 6.113

4.  Soluble intercellular adhesion molecule, vascular cell adhesion molecule, and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria.

Authors:  S C Lim; A E Caballero; P Smakowski; F W LoGerfo; E S Horton; A Veves
Journal:  Diabetes Care       Date:  1999-11       Impact factor: 19.112

5.  Amino acids as modulators of endothelium-derived nitric oxide.

Authors:  Masao Kakoki; Hyung-Suk Kim; Cora-Jean S Edgell; Nobuyo Maeda; Oliver Smithies; David L Mattson
Journal:  Am J Physiol Renal Physiol       Date:  2006-03-28

6.  Aortic leucine-to-glutamate pathway: metabolic route and regulation of contractile responses.

Authors:  David Schachter; James C Sang
Journal:  Am J Physiol Heart Circ Physiol       Date:  2002-03       Impact factor: 4.733

Review 7.  Vascular function, insulin resistance and fatty acids.

Authors:  H O Steinberg; A D Baron
Journal:  Diabetologia       Date:  2002-04-04       Impact factor: 10.122

Review 8.  Arginine metabolism: nitric oxide and beyond.

Authors:  G Wu; S M Morris
Journal:  Biochem J       Date:  1998-11-15       Impact factor: 3.857

9.  GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats.

Authors:  Cynthia J Meininger; Shijie Cai; Janet L Parker; Keith M Channon; Katherine A Kelly; Elizabeth J Becker; M Kathy Wood; Laura A Wade; Guoyao Wu
Journal:  FASEB J       Date:  2004-10-05       Impact factor: 5.191

Review 10.  Nitric oxide and vascular insulin resistance.

Authors:  Guoyao Wu; Cynthia J Meininger
Journal:  Biofactors       Date:  2009 Jan-Feb       Impact factor: 6.113
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  3 in total

1.  α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling.

Authors:  Yexian Yuan; Canjun Zhu; Yongliang Wang; Jia Sun; Jinlong Feng; Zewei Ma; Penglin Li; Wentong Peng; Cong Yin; Guli Xu; Pingwen Xu; Yuwei Jiang; Qingyan Jiang; Gang Shu
Journal:  Sci Adv       Date:  2022-05-04       Impact factor: 14.957

2.  Cholesterol Content, Fatty Acid Profile and Health Lipid Indices in the Egg Yolk of Eggs from Hens at the End of the Laying Cycle, Following Alpha-Ketoglutarate Supplementation.

Authors:  Ewa Tomaszewska; Siemowit Muszyński; Anna Arczewska-Włosek; Piotr Domaradzki; Renata Pyz-Łukasik; Janine Donaldson; Sylwester Świątkiewicz
Journal:  Foods       Date:  2021-03-11

3.  Alpha-Ketoglutarate Alleviates Neuronal Apoptosis Induced by Central Insulin Resistance through Inhibiting S6K1 Phosphorylation after Subarachnoid Hemorrhage.

Authors:  Peng-Fei Ding; Qi Zhu; Bin Sheng; Heng Yang; Hua-Jie Xu; Tao Tao; Zheng Peng; Xiang-Xin Chen; Xiao-Jian Li; Yan Zhou; Hua-Sheng Zhang; Yong-Yue Gao; Zong Zhuang; Chun-Hua Hang; Wei Li
Journal:  Oxid Med Cell Longev       Date:  2022-08-25       Impact factor: 7.310
  3 in total

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