Huixian Li1, Shifeng Yang1, Li Jin1, Zhigang Wang1, Liyi Xie1, Jing Lv1, Aiping Yin1, Wanhong Lu2. 1. Department of Nephrology, First Affiliated Hospital of Xian Jiaotong University, Xi'an, China. 2. Department of Nephrology, First Affiliated Hospital of Xian Jiaotong University, Xi'an, China, luwanhong@mail.xjtu.edu.cn.
Abstract
BACKGROUND: Peritoneal dialysis (PD) is a kind of renal replacement therapy (RRT), which can be employed to treat pediatric acute kidney injury (AKI) as it is safe, simple, and cost-effective. The studies of PD treatment in pediatric AKI in China have rarely been reported in English literature. OBJECTIVE: To investigate the efficacy and the outcome of PD in pediatric patients with AKI. METHODS: We performed a retrospective study of children who received PD as RRT for AKI in a teaching hospital in northwest China from 2003 to 2013. Demographic characteristics and laboratory data were collected, and the prognostic factors of renal recovery were identified. RESULTS: There were 24 children (62.5% male) identified, with the mean age of 22.4 ± 18.7 months (3 months to 5 years old). The most common causes of AKI were drug induced (25.0%), glomerulonephritis (20.9%), and obstructive nephropathy (16.7%). The mean duration of PD was 11.3 ± 7.8 days (2-39 days). PD treatment was highly effective in attenuation of toxics, improvement of fluid overload, and correction of electrolyte disturbances (p < 0.001). One catheter outflow obstruction was noted, and no major complication was identified. In total, 18 children (75.0%) recovered and had the catheter successfully removed, 2 (8.3%) needed further PD treatment, and 4 (16.7%) died. The albumin level was significantly higher in patients who recovered with PD treatment (33.7 ± 6.2 vs. 21.5 ± 4.8 g/L, p = 0.002). CONCLUSIONS: PD can be performed safely and efficiently for the treatment of pediatric AKI. Low albumin level may be associated with poor prognosis of pediatric AKI.
BACKGROUND: Peritoneal dialysis (PD) is a kind of renal replacement therapy (RRT), which can be employed to treat pediatric acute kidney injury (AKI) as it is safe, simple, and cost-effective. The studies of PD treatment in pediatric AKI in China have rarely been reported in English literature. OBJECTIVE: To investigate the efficacy and the outcome of PD in pediatric patients with AKI. METHODS: We performed a retrospective study of children who received PD as RRT for AKI in a teaching hospital in northwest China from 2003 to 2013. Demographic characteristics and laboratory data were collected, and the prognostic factors of renal recovery were identified. RESULTS: There were 24 children (62.5% male) identified, with the mean age of 22.4 ± 18.7 months (3 months to 5 years old). The most common causes of AKI were drug induced (25.0%), glomerulonephritis (20.9%), and obstructive nephropathy (16.7%). The mean duration of PD was 11.3 ± 7.8 days (2-39 days). PD treatment was highly effective in attenuation of toxics, improvement of fluid overload, and correction of electrolyte disturbances (p < 0.001). One catheter outflow obstruction was noted, and no major complication was identified. In total, 18 children (75.0%) recovered and had the catheter successfully removed, 2 (8.3%) needed further PD treatment, and 4 (16.7%) died. The albumin level was significantly higher in patients who recovered with PD treatment (33.7 ± 6.2 vs. 21.5 ± 4.8 g/L, p = 0.002). CONCLUSIONS:PD can be performed safely and efficiently for the treatment of pediatric AKI. Low albumin level may be associated with poor prognosis of pediatric AKI.
Authors: Paula A Coccia; Flavia B Ramírez; Angela D C Suárez; Laura F Alconcher; Alejandro Balestracci; Laura A García Chervo; Iliana Principi; Aída Vázquez; Viviana M Ratto; María Celia Planells; Jorge Montero; Mariana Saurit; Maria Graciela Pérez Y Gutiérrez; María Celeste Puga; Elsa M Isern; María Carolina Bettendorff; Marcela V Boscardin; Marta Bazán; Mario A Polischuk; Alejo De Sarrasqueta; Adriana Aralde; Diego B Ripeau; Daniela C Leroy; Nahir E Quijada; Romina S Escalante; Marta I Giordano; Cristian Sánchez; Verónica S Selva; Alejandra Caminiti; José María Ojeda; Pablo Bonany; Sandra E Morales; Daniel Allende; María Andrea Arias; Andrea M Exeni; Jésica D Geuna; Larisa Arrúa Journal: Pediatr Nephrol Date: 2021-01-04 Impact factor: 3.714