Literature DB >> 3135657

Epithelial HLA-DR expression and lymphocyte subsets in gastric mucosa in type B chronic gastritis.

C S Papadimitriou1, E E Ioachim-Velogianni, E B Tsianos, H M Moutsopoulos.   

Abstract

Lymphocyte subpopulations (B, T4, T8), monocytes/macrophages (LeuM5, KiM5) and HLA-DR antigen expression were studied immunohistochemically in frozen sections from 32 antral and 37 fundal biopsies of type-B chronic gastritis. Aberrant HLA-DR antigen expression in epithelial cells of gastric mucosa was found in all cases closely related to mononuclear infiltrates. Epithelial HLA-DR expression and mononuclear infiltrates were practically absent in foci of intestinal metaplasia. These findings suggest that an immunopathologic mechanism probably plays a role in initiation or perpetuation of type-B chronic gastritis.

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Year:  1988        PMID： 3135657     DOI： 10.1007/bf00718611

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN： 0174-7398


  33 in total

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