| Literature DB >> 3135514 |
J H Fischer1, A N Barr, F P Paloucek, J V Dorociak, A L Spunt.
Abstract
We evaluated the effect of food on the serum concentration profile of enteric-coated divalproex sodium (EC-VPA) in six adult volunteers following a single dose and in six patients during chronic-dose administration. The results demonstrated a significant delay but no decrease in extent of EC-VPA absorption following administration with food. To monitor serum concentrations in patients receiving EC-VPA, consideration of sampling time in relation both to time of dose and meals is required.Entities:
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Year: 1988 PMID： 3135514 DOI： 10.1212/wnl.38.8.1319
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910