Literature DB >> 3135513

'On-off' phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma.

T Eriksson1, A K Granérus, A Linde, A Carlsson.   

Abstract

Administration of a low-protein diet to parkinsonian patients with "on-off" syndromes consistently increased the total daily time of "on" states when compared with a high-protein diet. The clinical effect of the low-protein diet may be due to a marked decrease in the plasma concentration of large neutral amino acids that compete with L-dopa for carrier-mediated transport into the brain.

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Year:  1988        PMID: 3135513     DOI: 10.1212/wnl.38.8.1245

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  5 in total

Review 1.  Food-drug interactions.

Authors:  Lars E Schmidt; Kim Dalhoff
Journal:  Drugs       Date:  2002       Impact factor: 9.546

2.  The effects of oral protein on the absorption of intraduodenal levodopa and motor performance.

Authors:  J P Frankel; P A Kempster; M Bovingdon; R Webster; A J Lees; G M Stern
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-09       Impact factor: 10.154

3.  Influence of fluctuations of plasma large neutral amino acids with normal diets on the clinical response to levodopa.

Authors:  J G Nutt; W R Woodward; J H Carter; T L Trotman
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-04       Impact factor: 10.154

4.  Concurrent administration of donepezil HCl and levodopa/carbidopa in patients with Parkinson's disease: assessment of pharmacokinetic changes and safety following multiple oral doses.

Authors:  Chukwuemeka S Okereke; Louis Kirby; Dinesh Kumar; Edward I Cullen; Raymond D Pratt; William A Hahne
Journal:  Br J Clin Pharmacol       Date:  2004-11       Impact factor: 4.335

5.  Motor fluctuations due to interaction between dietary protein and levodopa in Parkinson's disease.

Authors:  Tuhin Virmani; Sirinan Tazan; Pietro Mazzoni; Blair Ford; Paul E Greene
Journal:  J Clin Mov Disord       Date:  2016-05-26
  5 in total

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