| Literature DB >> 3135321 |
S Banerjee1, B Y Wei, K Hillman, H S Luthra, C S David.
Abstract
The use of an anti-IL-2R antibody, 7D4, was investigated in vivo in the suppression of collagen-induced arthritis in mice. 7D4 was shown to reduce the incidence of arthritis in a group of mice immunized with type II collagen as compared with a group similarly immunized with collagen and treated with a control isotype matched anti-Forsmann antibody. 7D4 was also shown to reduce the severity of arthritis in the treated mice as compared to the mice in the group treated with the control antibody. Anti-IL-2R antibodies may be useful in the treatment of autoimmune diseases by selectively suppressing activated T cells.Entities:
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Year: 1988 PMID： 3135321
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422