| Literature DB >> 31353124 |
Jian Chen1, Julian A Gingold2, Xiaoping Su3.
Abstract
Hepatocellular carcinoma (HCC) is an inflammation-induced and chemotherapy-resistant cancer. Dysregulated signaling in the transforming growth factor beta (TGF-β) pathway plays a central role in inflammation, fibrogenesis, and immunomodulation in the HCC microenvironment. This review dissects the genetic landscape of the TGF-β superfamily genes in HCC and discusses the essential effects of this pathway on the tumor immune microenvironment. We highlight the TGF-β signature as a potential biomarker for identifying individualized immunotherapeutic approaches in HCC. An improved understanding of the detailed mechanisms of liver cancer immunogenicity and the specific role of TGF-β in mediating immunotherapy resistance in HCC will provide important insights into HCC immune escape and promote the development of biomarker-derived combination immunotherapies for HCC.Entities:
Keywords: TGF-β signaling; hepatocellular carcinoma; immune genomic profiling; immunotherapy; tumor microenvironment
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Year: 2019 PMID： 31353124 DOI： 10.1016/j.molmed.2019.06.007
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951