Vasiliki Michopoulos1, Eleonore Beurel1, Felicia Gould1, Firdaus S Dhabhar1, Katharina Schultebraucks1, Isaac Galatzer-Levy1, Barbara O Rothbaum1, Kerry J Ressler1, Charles B Nemeroff1. 1. The Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (Michopoulos, Rothbaum, Ressler); the Yerkes National Primate Research Center, Atlanta (Michopoulos); the Department of Psychiatry and Behavioral Sciences (Beurel, Gould, Dhabhar), the Department of Biochemistry and Molecular Biology (Beurel), and the Sylvester Comprehensive Cancer Center (Dhabhar), University of Miami Miller School of Medicine, Miami; the Department of Psychology, University of Miami, Coral Gables, Fla. (Dhabhar); the Department of Psychiatry, New York University School of Medicine, New York (Schultebraucks, Galatzer-Levy); Mclean Hospital, Harvard Medical School, Belmont, Mass. (Ressler); the Department of Psychiatry, Dell Medical School, and the Institute for Early Life Adversity Research, University of Texas at Austin (Nemeroff).
Abstract
OBJECTIVE: Although several reports have documented heightened systemic inflammation in posttraumatic stress disorder (PTSD), few studies have assessed whether inflammatory markers serve as prospective biomarkers for PTSD risk. The present study aimed to characterize whether peripheral immune factors measured in blood samples collected in an emergency department immediately after trauma exposure would predict later chronic development of PTSD. METHODS: Participants (N=505) were recruited from a hospital emergency department and underwent a 1.5-hour assessment. Blood samples were drawn, on average, about 3 hours after trauma exposure. Follow-up assessments were conducted 1, 3, 6, and 12 months after trauma exposure. Latent growth mixture modeling was used to identify classes of PTSD symptom trajectories. RESULTS: Three distinct classes of PTSD symptom trajectories were identified: chronic (N=28), resilient (N=160), and recovery (N=85). Multivariate analyses of covariance revealed a significant multivariate main effect of PTSD symptom trajectory class membership on proinflammatory cytokines. Univariate analyses showed a significant main effect of trajectory class membership on plasma concentrations of proinflammatory tumor necrosis factor α (TNFα) and interferon-γ (IFNγ). Concentrations of proinflammatory TNFα and IFNγ were significantly lower in individuals in the chronic PTSD class compared with those in the recovery and resilient classes. There were no significant differences in interleukin (IL) 1β and IL-6 concentrations by PTSD symptom trajectory class. Anti-inflammatory and other cytokines, as well as chemokines and growth factor concentrations, were not associated with development of chronic PTSD. CONCLUSIONS: Overall, the study findings suggest that assessing the proinflammatory immune response to trauma exposure immediately after trauma exposure, in the emergency department, may help identify individuals most at risk for developing chronic PTSD in the aftermath of trauma.
OBJECTIVE: Although several reports have documented heightened systemic inflammation in posttraumatic stress disorder (PTSD), few studies have assessed whether inflammatory markers serve as prospective biomarkers for PTSD risk. The present study aimed to characterize whether peripheral immune factors measured in blood samples collected in an emergency department immediately after trauma exposure would predict later chronic development of PTSD. METHODS:Participants (N=505) were recruited from a hospital emergency department and underwent a 1.5-hour assessment. Blood samples were drawn, on average, about 3 hours after trauma exposure. Follow-up assessments were conducted 1, 3, 6, and 12 months after trauma exposure. Latent growth mixture modeling was used to identify classes of PTSD symptom trajectories. RESULTS: Three distinct classes of PTSD symptom trajectories were identified: chronic (N=28), resilient (N=160), and recovery (N=85). Multivariate analyses of covariance revealed a significant multivariate main effect of PTSD symptom trajectory class membership on proinflammatory cytokines. Univariate analyses showed a significant main effect of trajectory class membership on plasma concentrations of proinflammatory tumor necrosis factor α (TNFα) and interferon-γ (IFNγ). Concentrations of proinflammatory TNFα and IFNγ were significantly lower in individuals in the chronic PTSD class compared with those in the recovery and resilient classes. There were no significant differences in interleukin (IL) 1β and IL-6 concentrations by PTSD symptom trajectory class. Anti-inflammatory and other cytokines, as well as chemokines and growth factor concentrations, were not associated with development of chronic PTSD. CONCLUSIONS: Overall, the study findings suggest that assessing the proinflammatory immune response to trauma exposure immediately after trauma exposure, in the emergency department, may help identify individuals most at risk for developing chronic PTSD in the aftermath of trauma.
Authors: Jennifer A Sumner; Kristen M Nishimi; Karestan C Koenen; Andrea L Roberts; Laura D Kubzansky Journal: Biol Psychiatry Date: 2019-11-14 Impact factor: 13.382
Authors: Alyssa R Roeckner; Shivangi Sogani; Vasiliki Michopoulos; Rebecca Hinrichs; Sanne J H van Rooij; Barbara O Rothbaum; Tanja Jovanovic; Kerry J Ressler; Jennifer S Stevens Journal: Neuropsychopharmacology Date: 2022-09-16 Impact factor: 8.294
Authors: Kerry J Ressler; Sabina Berretta; Vadim Y Bolshakov; Isabelle M Rosso; Edward G Meloni; Scott L Rauch; William A Carlezon Journal: Nat Rev Neurol Date: 2022-03-29 Impact factor: 44.711
Authors: Laura M Hack; Shota Nishitani; Anna K Knight; Varun Kilaru; Stephanie A Maddox; Antonia V Seligowski; Tanja Jovanovic; Kerry J Ressler; Alicia K Smith; Vasiliki Michopoulos Journal: Compr Psychoneuroendocrinol Date: 2021-03-09
Authors: Adriana Lori; Katharina Schultebraucks; Isaac Galatzer-Levy; Nikolaos P Daskalakis; Seyma Katrinli; Alicia K Smith; Amanda J Myers; Ryan Richholt; Matthew Huentelman; Guia Guffanti; Stefan Wuchty; Felicia Gould; Philip D Harvey; Charles B Nemeroff; Tanja Jovanovic; Ekaterina S Gerasimov; Jessica L Maples-Keller; Jennifer S Stevens; Vasiliki Michopoulos; Barbara O Rothbaum; Aliza P Wingo; Kerry J Ressler Journal: Neuropsychopharmacology Date: 2021-06-29 Impact factor: 8.294