Natalie Szpakowski1, Milind Y Desai2. 1. Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Desk J1-5, Cleveland, OH, 44195, USA. 2. Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Desk J1-5, Cleveland, OH, 44195, USA. desaim2@ccf.org.
Abstract
PURPOSE OF REVIEW: This review highlights the literature related to pericardial injury following radiation for oncologic diseases. RECENT FINDINGS: Radiation-associated pericardial disease can have devastating consequences. Unfortunately, there is considerably less evidence regarding pericardial syndromes following thoracic radiation as compared to other cardiovascular outcomes. Pericardial complications of radiation may arise acutely or have an insidious onset several decades after treatment. Transthoracic echocardiography is the screening imaging modality of choice, while cardiac magnetic resonance imaging further characterizes the pericardium and guides treatment decision-making. Cardiac CT can be useful for assessing pericardial calcification. Ongoing efforts to lessen inadvertent cardiac injury are directed towards the revision of radiation techniques and protocols. As survival of mediastinal and thoracic malignancies continues to improve, radiation-associated pericardial disease is increasingly relevant. Though advances in radiation oncology demonstrate promise in curtailing cardiotoxicity, the long-term effects pertaining to pericardial complications remain to be seen.
PURPOSE OF REVIEW: This review highlights the literature related to pericardial injury following radiation for oncologic diseases. RECENT FINDINGS: Radiation-associated pericardial disease can have devastating consequences. Unfortunately, there is considerably less evidence regarding pericardial syndromes following thoracic radiation as compared to other cardiovascular outcomes. Pericardial complications of radiation may arise acutely or have an insidious onset several decades after treatment. Transthoracic echocardiography is the screening imaging modality of choice, while cardiac magnetic resonance imaging further characterizes the pericardium and guides treatment decision-making. Cardiac CT can be useful for assessing pericardial calcification. Ongoing efforts to lessen inadvertent cardiac injury are directed towards the revision of radiation techniques and protocols. As survival of mediastinal and thoracic malignancies continues to improve, radiation-associated pericardial disease is increasingly relevant. Though advances in radiation oncology demonstrate promise in curtailing cardiotoxicity, the long-term effects pertaining to pericardial complications remain to be seen.
Authors: M Jacob Adams; Patricia H Hardenbergh; Louis S Constine; Steven E Lipshultz Journal: Crit Rev Oncol Hematol Date: 2003-01 Impact factor: 6.312
Authors: Xiong Wei; H Helen Liu; Susan L Tucker; Shulian Wang; Radhe Mohan; James D Cox; Ritsuko Komaki; Zhongxing Liao Journal: Int J Radiat Oncol Biol Phys Date: 2008-01-11 Impact factor: 7.038
Authors: Christina S Reuss; Susan M Wilansky; Steven J Lester; Joan L Lusk; Diane E Grill; Jae K Oh; A Jamil Tajik Journal: Eur J Echocardiogr Date: 2008-10-24
Authors: Deepak R Talreja; William D Edwards; Gordon K Danielson; Hartzell V Schaff; A Jamil Tajik; Henry D Tazelaar; Jerome F Breen; Jae K Oh Journal: Circulation Date: 2003-09-29 Impact factor: 29.690
Authors: Stefan C Bertog; Senthil K Thambidorai; Kapil Parakh; Paul Schoenhagen; Volkan Ozduran; Penny L Houghtaling; Bruce W Lytle; Eugene H Blackstone; Michael S Lauer; Allan L Klein Journal: J Am Coll Cardiol Date: 2004-04-21 Impact factor: 24.094
Authors: C W Taylor; P McGale; J M Povall; E Thomas; S Kumar; D Dodwell; S C Darby Journal: Int J Radiat Oncol Biol Phys Date: 2008-10-28 Impact factor: 7.038