| Literature DB >> 31352487 |
Camilla N O Santos1, Danielle R Ribeiro2, Juliana Cardoso Alves1, Rodrigo A Cazzaniga2, Lucas S Magalhães1, Mércia S F de Souza3, Adriana B L Fonseca4, Ana J B Bispo4, Roseane L S Porto4, Cliomar Alves Dos Santos5, Ângela M da Silva6, Mauro M Teixeira7, Roque P de Almeida1,8, Amélia R de Jesus1,8.
Abstract
Congenital Zika syndrome (CZS) is a cluster of malformation, and the mechanisms that lead it are still unclear. Using hypothesis-driven candidate genes and their function in viral infections, single-nucleotide polymorphisms (SNPs) were genotyped by quantitative polymerase chain reaction in a sample population from Sergipe State, Brazil. This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon antiviral responses in mothers infected by Zika virus during pregnancy, is associated with CZS occurrence (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.158-4.148). Moreover, rs1799964 SNP at tumor necrosis factor-α gene in CZS babies is associated with severe microcephaly (OR, 2.63; 95% CI, 1.13-6.21).Entities:
Keywords: TLR3; TNFα; congenital Zika syndrome; microcephaly; polymorphism
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Year: 2019 PMID： 31352487 DOI： 10.1093/infdis/jiz392
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226