Florent Besnier1, Marc Labrunée2, Lisa Richard3, Florence Faggianelli4, Hélène Kerros3, Laurent Soukarié3, Marc Bousquet3, Jean-Louis Garcia3, Atul Pathak5, Céline Gales6, Thibaut Guiraud7, Jean Michel Sénard8. 1. Institute of Cardiovascular and Metabolic Diseases, National Institute of Health and Medical Research (Inserm), UMR-1048, 1, avenue Professeur Jean-Poulhès, BP 84225, 31432, Toulouse, France; ELSAN, Clinic of Saint-Orens, Cardiovascular and Pulmonary Rehabilitation Center, 12 avenue de Revel, 31650, Saint-Orens-de-Gameville, France. 2. Institute of Cardiovascular and Metabolic Diseases, National Institute of Health and Medical Research (Inserm), UMR-1048, 1, avenue Professeur Jean-Poulhès, BP 84225, 31432, Toulouse, France; Department of Cardiovascular Rehabilitation, Toulouse University Hospital, 1 avenue du Professeur Jean Poulhès, 31400, Toulouse, France. 3. ELSAN, Clinic of Saint-Orens, Cardiovascular and Pulmonary Rehabilitation Center, 12 avenue de Revel, 31650, Saint-Orens-de-Gameville, France. 4. Department of Cardiovascular Rehabilitation, Toulouse University Hospital, 1 avenue du Professeur Jean Poulhès, 31400, Toulouse, France. 5. Institute of Cardiovascular and Metabolic Diseases, National Institute of Health and Medical Research (Inserm), UMR-1048, 1, avenue Professeur Jean-Poulhès, BP 84225, 31432, Toulouse, France; Department of Cardiovascular Medicine, Hypertension and Heart Failure Unit, Clinique Pasteur, 45 avenue de Lombez - BP 27617, 31076, Toulouse, France. 6. Institute of Cardiovascular and Metabolic Diseases, National Institute of Health and Medical Research (Inserm), UMR-1048, 1, avenue Professeur Jean-Poulhès, BP 84225, 31432, Toulouse, France. 7. Institute of Cardiovascular and Metabolic Diseases, National Institute of Health and Medical Research (Inserm), UMR-1048, 1, avenue Professeur Jean-Poulhès, BP 84225, 31432, Toulouse, France. Electronic address: thibaut.guiraud@gmail.com. 8. Institute of Cardiovascular and Metabolic Diseases, National Institute of Health and Medical Research (Inserm), UMR-1048, 1, avenue Professeur Jean-Poulhès, BP 84225, 31432, Toulouse, France; Department of Clinical Pharmacology, Toulouse University Hospital, 1 avenue du Professeur Jean Poulhès, 31400, Toulouse, France.
Abstract
BACKGROUND: Exaggerated sympathetic nervous system activity associated with low heart rate variability (HRV) is considered to trigger cardiac arrhythmias and sudden death. Regular exercise training is efficient to improve autonomic balance. OBJECTIVE: We aimed to verify the superiority of high-intensity interval training (HIIT) to enhance HRV, cardiorespiratory fitness and cardiac function as compared with moderate intensity continuous training (MICT) in a short, intense cardiac rehabilitation program. METHODS: This was a prospective, monocentric, evaluator-blinded, randomised (1:1) study with a parallel two-group design. Overall, 31 individuals with voluntary chronic heart failure (CHF) (left ventricular ejection fraction [LVEF]<45%) were allocated to MICT (n=15) or HIIT (n=16) for a short rehabilitation program (mean [SD] 27 [4] days). Participants underwent 24-hr electrocardiography, echocardiography and a cardiopulmonary exercise test at entry and at the end of the study. RESULTS:High-frequency power in normalized units (HFnu%) measured as HRV increased with HIIT (from 21.2% to 26.4%, P<0.001) but remained unchanged with MICT (from 23.1% to 21.9%, P=0.444, with a significant intergroup difference, P=0.003). Resting heart rate (24-hr Holter electrocardiography) decreased significantly for both groups (from 68.2 to 64.6 bpm and 66.0 to 63.5 bpm for MICT and HIIT, respectively, with no intergroup difference, P=0.578). The 2 groups did not differ in premature ventricular contractions. Improvement in peak oxygen uptake was greater with HIIT than MICT (+21% vs. +5%, P=0.009). LVEF improved with only HIIT (from 36.2% to 39.5%, P=0.034). CONCLUSIONS: In this short rehabilitation program, HIIT was significantly superior to the classical MICT program for enhancing parasympathetic tone and peak oxygen uptake. CLINICALTRIALS. GOV IDENTIFIER: NCT03603743.
RCT Entities:
BACKGROUND: Exaggerated sympathetic nervous system activity associated with low heart rate variability (HRV) is considered to trigger cardiac arrhythmias and sudden death. Regular exercise training is efficient to improve autonomic balance. OBJECTIVE: We aimed to verify the superiority of high-intensity interval training (HIIT) to enhance HRV, cardiorespiratory fitness and cardiac function as compared with moderate intensity continuous training (MICT) in a short, intense cardiac rehabilitation program. METHODS: This was a prospective, monocentric, evaluator-blinded, randomised (1:1) study with a parallel two-group design. Overall, 31 individuals with voluntary chronic heart failure (CHF) (left ventricular ejection fraction [LVEF]<45%) were allocated to MICT (n=15) or HIIT (n=16) for a short rehabilitation program (mean [SD] 27 [4] days). Participants underwent 24-hr electrocardiography, echocardiography and a cardiopulmonary exercise test at entry and at the end of the study. RESULTS: High-frequency power in normalized units (HFnu%) measured as HRV increased with HIIT (from 21.2% to 26.4%, P<0.001) but remained unchanged with MICT (from 23.1% to 21.9%, P=0.444, with a significant intergroup difference, P=0.003). Resting heart rate (24-hr Holter electrocardiography) decreased significantly for both groups (from 68.2 to 64.6 bpm and 66.0 to 63.5 bpm for MICT and HIIT, respectively, with no intergroup difference, P=0.578). The 2 groups did not differ in premature ventricular contractions. Improvement in peak oxygen uptake was greater with HIIT than MICT (+21% vs. +5%, P=0.009). LVEF improved with only HIIT (from 36.2% to 39.5%, P=0.034). CONCLUSIONS: In this short rehabilitation program, HIIT was significantly superior to the classical MICT program for enhancing parasympathetic tone and peak oxygen uptake. CLINICALTRIALS. GOV IDENTIFIER: NCT03603743.
Authors: Silvio A Oliveira-Junior; Daniel Boullosa; Maria L M Mendonça; Larissa F C Vieira; Wania W Mattos; Bruna O C Amaral; Dayanne S Lima-Borges; Filipe A Reis; Marcelo D M Cezar; Luiz C M Vanderlei; Paula F Martinez Journal: Int J Environ Res Public Health Date: 2021-04-27 Impact factor: 3.390
Authors: Jordana Oliveira; Paulo Gentil; João Pedro Naves; Luiz Fernando Souza Filho; Lucas Silva; Antonio Roberto Zamunér; Claudio Andre de Lira; Ana Rebelo Journal: Int J Environ Res Public Health Date: 2022-10-08 Impact factor: 4.614