Daniele de Cassia Rodrigues Picco1, Leonardo Lobo Ribeiro Cavalcante2, Rayana Longo Bighetti Trevisan3, Aline Evangelista Souza-Gabriel4, Maria Cristina Borsatto5, Silmara Aparecida Milori Corona6. 1. Department of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo - Café Av, Ribeirão Preto, São Paulo, 14040-904, Brazil. Electronic address: danielepicco@outlook.com. 2. Department of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo - Café Av, Ribeirão Preto, São Paulo, 14040-904, Brazil. Electronic address: leonardolobo@usp.br. 3. Department of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo - Café Av, Ribeirão Preto, São Paulo, 14040-904, Brazil. Electronic address: rayana.longo@gmail.com. 4. Department of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo - Café Av, Ribeirão Preto, São Paulo, 14040-904, Brazil. Electronic address: aline.gabriel@forp.usp.br. 5. Department of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo - Café Av, Ribeirão Preto, São Paulo, 14040-904, Brazil. Electronic address: borsatto@forp.usp.br. 6. Department of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo - Café Av, Ribeirão Preto, São Paulo, 14040-904, Brazil. Electronic address: silmaracorona@forp.usp.br.
Abstract
BACKGROUND: There is still no systematized evidence in the literature regarding the combination of curcumin to improve the effects of antimicrobial photodynamic therapy (aPDT) on complex oral biofilms. Therefore, the objective of this review was to systematically assess the antimicrobial effect of curcumin-mediated aPDT on the vitality of biofilms of microorganisms Streptococcus mutans and Candida albicans. METHODS: The addressed focused question was: "What are the effects of curcumin-mediated antimicrobial therapy on the biofilm viability of Streptococcus mutans and Candida albicans in vitro models?" A literature search was conducted in the electronic databases Pubmed, Web of Science, Scopus, Cochrane Library and Bireme up to April 2019. In vitro studies evaluating the effect of curcumin-mediated antimicrobial photodynamic therapy on S. mutans and C. albicans biofilms were included. RESULTS: From 95 citations, 11 full-text articles were screened and 6 studies were included in this review. Because of the heterogeneity observed in the studies selected, meta-analysis was not possible. CONCLUSIONS: The in vitro studies indicate the potential use of curcumin-mediated aPDT to inactivate microorganisms; Streptococcus mutans and Candida albicans. This survey should be viewed as a starting point for further examinations using standardized parameters to enhance outcomes.
BACKGROUND: There is still no systematized evidence in the literature regarding the combination of curcumin to improve the effects of antimicrobial photodynamic therapy (aPDT) on complex oral biofilms. Therefore, the objective of this review was to systematically assess the antimicrobial effect of curcumin-mediated aPDT on the vitality of biofilms of microorganisms Streptococcus mutans and Candida albicans. METHODS: The addressed focused question was: "What are the effects of curcumin-mediated antimicrobial therapy on the biofilm viability of Streptococcus mutans and Candida albicans in vitro models?" A literature search was conducted in the electronic databases Pubmed, Web of Science, Scopus, Cochrane Library and Bireme up to April 2019. In vitro studies evaluating the effect of curcumin-mediated antimicrobial photodynamic therapy on S. mutans and C. albicans biofilms were included. RESULTS: From 95 citations, 11 full-text articles were screened and 6 studies were included in this review. Because of the heterogeneity observed in the studies selected, meta-analysis was not possible. CONCLUSIONS: The in vitro studies indicate the potential use of curcumin-mediated aPDT to inactivate microorganisms; Streptococcus mutans and Candida albicans. This survey should be viewed as a starting point for further examinations using standardized parameters to enhance outcomes.
Authors: Vanessa Marques Meccatti; Larissa de Souza Moura; Juliana Guerra Pinto; Juliana Ferreira-Strixino; Amjad Abu Hasna; Lívia Mara Alves Figueiredo-Godoi; Juliana Campos Junqueira; Maria Cristina Marcucci; Lucas de Paula Ramos; Claudio Antonio Talge Carvalho; Cesar Rogério Pucci; Luciane Dias de Oliveira Journal: Int J Dent Date: 2022-07-01