Literature DB >> 31351082

The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers.

Kim San Tang1.   

Abstract

Alzheimer's disease (AD) is neurodegenerative disorder that is associated with memory and cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model in studying cognitive disorders including AD. Many studies have also concurrently examined the neurochemical mechanisms underlying the behavioral modifications by scopolamine treatment. Nonetheless, the scopolamine model has not become a standard tool in the early assessment of drugs. Furthermore, the use of scopolamine as a pharmacological model to study AD remains debatable. This report reviews the scopolamine-induced cellular and molecular changes and discusses how these changes relate to AD pathogenesis.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Amyloid beta-peptides; Apoptosis; Dementia; Inflammation; Oxidative stress; Scopolamine; Tau proteins

Mesh：

Substances：

Year:  2019        PMID： 31351082     DOI： 10.1016/j.lfs.2019.116695

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  23 in total

1.  Neuroprotective Effects of Apocynin and Galantamine During the Chronic Administration of Scopolamine in an Alzheimer's Disease Model.

Authors:  Eliezer Joseph; Daniel Miguel Ángel Villalobos-Acosta; Mónica Adriana Torres-Ramos; Eunice Dalet Farfán-García; Modesto Gómez-López; Ángel Miliar-García; Manuel Jonathan Fragoso-Vázquez; Iohanan Daniel García-Marín; José Correa-Basurto; Martha Cecilia Rosales-Hernández
Journal:  J Mol Neurosci       Date:  2019-11-25       Impact factor: 3.444

2.  Chronic Administration of Scopolamine Increased GSK3βP9, Beta Secretase, Amyloid Beta, and Oxidative Stress in the Hippocampus of Wistar Rats.

Authors:  Maricarmen Hernández-Rodríguez; Ivonne Maciel Arciniega-Martínez; Iohanan Daniel García-Marín; José Correa-Basurto; Martha Cecilia Rosales-Hernández
Journal:  Mol Neurobiol       Date:  2020-07-07       Impact factor: 5.590

3.  The effect of maslinic acid on cognitive dysfunction induced by cholinergic blockade in mice.

Authors:  Ho Jung Bae; Jihyun Kim; Jaehoon Kim; Nayeon Goo; Mudan Cai; Kyungnam Cho; Seo Yun Jung; Huiyoung Kwon; Dong Hyun Kim; Dae Sik Jang; Jong Hoon Ryu
Journal:  Br J Pharmacol       Date:  2020-04-01       Impact factor: 8.739

4.  Protective Effects of Inosine on Memory Consolidation in a Rat Model of Scopolamine-Induced Cognitive Impairment: Involvement of Cholinergic Signaling, Redox Status, and Ion Pump Activities.

Authors:  Fernanda Cardoso Teixeira; Bruna da Silveira de Mattos; Julia Eisenhardt de Mello; Juliane Cardoso; Luiza Spohr; Karina Pereira Luduvico; Mayara Sandrielly Pereira Soares; Fabiano Barbosa Carvalho; Jessie Martins Gutierres; Anelize de Oliveira Campello Felix; Francieli Moro Stefanello; Roselia Maria Spanevello
Journal:  Neurochem Res       Date:  2021-10-08       Impact factor: 3.996

5.  A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats.

Authors:  Asli Aykac; Kerem Teralı; Dilek Özbeyli; Seren Ede; Ömercan Albayrak; Kemal Hüsnü Can Başer; Göksel Şener
Journal:  Metab Brain Dis       Date:  2022-02-24       Impact factor: 3.584

6.  Protective effects of vitamin D on learning and memory deficit induced by scopolamine in male rats: the roles of brain-derived neurotrophic factor and oxidative stress.

Authors:  Fatemeh Mansouri; Hamideh Ghanbari; Narges Marefati; Zohre Arab; Hossein Salmani; Farimah Beheshti; Mahmoud Hosseini
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2021-03-02       Impact factor: 3.000

7.  Tert-butyl-(4-hydroxy-3-((3-(2-methylpiperidin-yl)propyl)carbamoyl)phenyl)carbamate Has Moderated Protective Activity in Astrocytes Stimulated with Amyloid Beta 1-42 and in a Scopolamine Model.

Authors:  Raúl Horacio Camarillo-López; Maricarmen Hernández Rodríguez; Mónica Adriana Torres-Ramos; Ivonne Maciel Arciniega-Martínez; Iohanan Daniel García-Marín; José Correa Basurto; Juan Vicente Méndez Méndez; Martha Cecilia Rosales-Hernández
Journal:  Molecules       Date:  2020-10-29       Impact factor: 4.411

8.  Influence of Acetylcholine Esterase Inhibitors and Memantine, Clinically Approved for Alzheimer's Dementia Treatment, on Intestinal Properties of the Mouse.

Authors:  Vu Thu Thuy Nguyen; Jason Sallbach; Malena Dos Santos Guilherme; Kristina Endres
Journal:  Int J Mol Sci       Date:  2021-01-20       Impact factor: 5.923

Review 9.  Potential of Caffeine in Alzheimer's Disease-A Review of Experimental Studies.

Authors:  Piotr Londzin; Milena Zamora; Beata Kąkol; Aleksandra Taborek; Joanna Folwarczna
Journal:  Nutrients       Date:  2021-02-06       Impact factor: 5.717

10.  Central Administration of Ampelopsin A Isolated from Vitis vinifera Ameliorates Cognitive and Memory Function in a Scopolamine-Induced Dementia Model.

Authors:  Yuni Hong; Yun-Hyeok Choi; Young-Eun Han; Soo-Jin Oh; Ansoo Lee; Bonggi Lee; Rebecca Magnan; Shi Yong Ryu; Chun Whan Choi; Min Soo Kim
Journal:  Antioxidants (Basel)       Date:  2021-05-24
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